{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T22:12:29Z","timestamp":1776118349290,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[1995,9,1]]},"abstract":"<jats:p> Modulation of Ca2+ channels during repetitive activity in excitable cells can have an important role in altering cellular function. In mammalian parasympathetic and dorsal root ganglion neurons, L-type Ca2+ channels are potentiated by single depolarizing prepulses or trains of short high-frequency depolarizing pulses. This type of potentiation takes place regardless of whether Ca2+ or Ba2+ is the charge carrier and requires phosphorylation by a adenosine 3',5'-cyclic monophosphate (cAMP)-dependent protein kinase. The magnitude of facilitation was correlated with frequency of conditioning trains, was enhanced by 8-bromoadenosine 3',5'-cyclic monophosphate or the Sp diastereomer of adenosine 3',5'-cyclic monophosphothioate (cAMPS), and reduced by Rp-cAMPS or a peptide inhibitor of cAMP-dependent protein kinase. The N-type Ca2+ channels exhibited the opposite response to these agents. We propose that the potentiation of L-type Ca2+ channel currents in neurons is due to state-dependent phosphorylation by cAMP-dependent protein kinase (Sculptoreanu, A., T. Scheuer, and W. A. Catterall. Nature Lond. 364: 240-243, 1993; Sculptoreanu, A., E. Rotman, M. Takahashi, T. Scheuer, and W. A. Catterall. Proc. Natl. Acad. Sci. USA 90: 10135-10139, 1993.). Thus state-dependent phosphorylation in neurons may be a mechanism for the regulation of various functions including transmitter release. <\/jats:p>","DOI":"10.1152\/ajpcell.1995.269.3.c725","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T18:23:30Z","timestamp":1514139810000},"page":"C725-C732","source":"Crossref","is-referenced-by-count":61,"title":["Voltage-dependent potentiation of neuronal L-type calcium channels due to state-dependent phosphorylation"],"prefix":"10.1152","volume":"269","author":[{"given":"A.","family":"Sculptoreanu","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Pittsburgh, Pennsylvania15261, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Figourov","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Pittsburgh, Pennsylvania15261, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. C.","family":"De Groat","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Pittsburgh, Pennsylvania15261, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.1995.269.3.C725","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T19:37:11Z","timestamp":1718653031000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.1995.269.3.C725"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,9,1]]}},"alternative-id":["10.1152\/ajpcell.1995.269.3.C725"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.1995.269.3.c725","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9,1]]}}}