{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:58:15Z","timestamp":1773287895859,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[1996,5,1]]},"abstract":"<jats:p> The contributions of various K+ transport pathways in bovine chondrocytes isolated from articular cartilage and their responses to changes in cell volume have been studied. K+(86Rb+) uptake mediated by the Na(+)-K(+) pump and Na(+)-K(+)-2Cl- cotransporter were stimulated by cell shrinkage, the latter as part of the regulatory volume increases (RVI) response, the former as an indirect effect resulting from the rise in intracellular Na+ concentration during RVI. For both transporters, there was an increase in the maximum velocity with no detectable effect on the Michaelis constant. There was no evidence for volume-sensitive K+ transport mediated by the K(+)-Cl- cotransporter, or Ca(2+)-activated K+ channels. However, chondrocyte swelling stimulated a ouabain- and bumetanide-insensitive K+ flux sensitive to pimozide and other drugs, which exhibited some of the properties of the relatively nonspecific volume-sensitive \"osmolyte\" channel described in other cell types. <\/jats:p>","DOI":"10.1152\/ajpcell.1996.270.5.c1300","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T19:15:36Z","timestamp":1514142936000},"page":"C1300-C1310","source":"Crossref","is-referenced-by-count":41,"title":["Pathways for K+ transport across the bovine articular chondrocyte membrane and their sensitivity to cell volume"],"prefix":"10.1152","volume":"270","author":[{"given":"A. C.","family":"Hall","sequence":"first","affiliation":[{"name":"University Laboratory of Physiology, Oxford, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Starks","sequence":"additional","affiliation":[{"name":"University Laboratory of Physiology, Oxford, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. L.","family":"Shoults","sequence":"additional","affiliation":[{"name":"University Laboratory of Physiology, Oxford, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Rashidbigi","sequence":"additional","affiliation":[{"name":"University Laboratory of Physiology, Oxford, United Kingdom."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.1996.270.5.C1300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T19:35:07Z","timestamp":1718652907000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.1996.270.5.C1300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1996,5,1]]}},"alternative-id":["10.1152\/ajpcell.1996.270.5.C1300"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.1996.270.5.c1300","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,5,1]]}}}