{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T11:50:35Z","timestamp":1759665035621},"reference-count":0,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[1996,8,1]]},"abstract":"<jats:p> Male weanling Sprague-Dawley rats were assigned to copper-deficient (9.0 mumol Cu\/kg diet) or copper-adequate (102 mumol Cu\/kg diet) dietary treatments for 6 wk. Pulse-chase studies using freshly isolated rat liver parenchymal cells demonstrated that apolipoprotein B (apoB)-48 and apoB-100 syntheses were not altered, but secretion was increased twofold in hepatocytes derived from copper-deficient rats. Both plasma apoB-48 and apoB-100 levels were increased by copper deficiency, but only the apoB-48 increase was significant. Hepatic apoB mRNA editing, expressed as a ratio of apoB-48 mRNA to apoB-48 plus apoB-100 mRNA, was significantly increased from 60.8% in copper-adequate to 70.2% in copper-deficient rats. Moreover, hepatic apoB mRNA abundance was not significantly altered by copper deficiency. Thus the increased amount of nascent apoB-48 secreted into the medium as well as the enhanced apoB mRNA editing may have contributed to the differential increase in plasma apoB-48 over apoB-100 level in copper-deficient rats. <\/jats:p>","DOI":"10.1152\/ajpcell.1996.271.2.c595","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T19:56:56Z","timestamp":1514145416000},"page":"C595-C604","source":"Crossref","is-referenced-by-count":23,"title":["Copper deficiency increases hepatic apolipoprotein B secretion and mRNA editing in rats"],"prefix":"10.1152","volume":"271","author":[{"given":"S. K.","family":"Reaves","sequence":"first","affiliation":[{"name":"Department of Nutritional Sciences, University of Arizona, Tucson85721, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. C.","family":"Hoogeveen","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Arizona, Tucson85721, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. R.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Arizona, Tucson85721, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Y.","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Arizona, Tucson85721, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Y.","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Arizona, Tucson85721, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.1996.271.2.C595","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T19:36:21Z","timestamp":1718652981000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.1996.271.2.C595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,8,1]]}},"alternative-id":["10.1152\/ajpcell.1996.271.2.C595"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.1996.271.2.c595","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,8,1]]}}}