{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:15:59Z","timestamp":1779894959627,"version":"3.53.1"},"reference-count":29,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:p> The effects of cyanide (CN) on whole cell current measured with the perforated-patch method were studied in adrenal medullary cells. Application of CN produced initially inward and then outward currents at \u221252 mV or more negative. As the membrane potential was hyperpolarized, amplitude and latency of the outward current ( I <jats:sub>o<\/jats:sub>) by CN became small and long, respectively. A decrease in the external Na<jats:sup>+<\/jats:sup> concentration did not affect the latency for CN-induced I <jats:sub>o<\/jats:sub> but enhanced the amplitude markedly. The CN I <jats:sub>o<\/jats:sub> reversed polarity at \u221285 mV, close to the Nernst potential for K<jats:sup>+<\/jats:sup>, and was suppressed by the K<jats:sup>+<\/jats:sup> channel blockers curare and apamin but not by glibenclamide, suggesting that I <jats:sub>o<\/jats:sub> is due to the activation of Ca<jats:sup>2+<\/jats:sup>-dependent K<jats:sup>+<\/jats:sup> channels. Consistent with this notion, the Ca<jats:sup>2+<\/jats:sup>-mobilizing agents, muscarine and caffeine, also produced I <jats:sub>o<\/jats:sub>. Exposure to CN in a Ca<jats:sup>2+<\/jats:sup>-deficient medium for 4 min abolished caffeine- or muscarine-induced I <jats:sub>o<\/jats:sub> without development of I <jats:sub>o<\/jats:sub>, and addition of Ca<jats:sup>2+<\/jats:sup> to the CN-containing solution induced I <jats:sub>o<\/jats:sub>. We conclude that exposure to CN produces Ca<jats:sup>2+<\/jats:sup>-dependent K<jats:sup>+<\/jats:sup> currents in an external Ca<jats:sup>2+<\/jats:sup>-dependent manner, probably via facilitation of Ca<jats:sup>2+<\/jats:sup> influx. <\/jats:p>","DOI":"10.1152\/ajpcell.1998.274.1.c105","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T16:49:48Z","timestamp":1514134188000},"page":"C105-C111","source":"Crossref","is-referenced-by-count":16,"title":["Activation of Ca<sup>2+<\/sup>-dependent K<sup>+<\/sup> channels by cyanide  in guinea pig adrenal chromaffin cells"],"prefix":"10.1152","volume":"274","author":[{"given":"M.","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine, Fukuoka University, Fukuoka 814\u201301, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Imanaga","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Fukuoka University, Fukuoka 814\u201301, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020833"},{"issue":"2","key":"B2","first-page":"L271","volume":"258","author":"Biscoe T. J.","year":"1990","journal-title":"Am. J. Physiol."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/323718a0"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1948.sp004265"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.10-08-02493.1990"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198008213030806"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018073"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1990.sp018074"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80038-0"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.92.2.145"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.265.4.C946"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb13243.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.40.679"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s002329900143"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00029-K"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.273.1.C137"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-06-02002.1996"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1994.1151"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/BF00581321"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/291497a0"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/313316a0"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.107.1.133"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019220"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90412-8"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(89)90029-1"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1021\/jm00168a001"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)84646-X"},{"key":"B28","first-page":"207","volume":"183","author":"Unsicker K.","year":"1993","journal-title":"J. Anat."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.14-01-00348.1994"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.1998.274.1.C105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T19:28:49Z","timestamp":1718652529000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.1998.274.1.C105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1,1]]}},"alternative-id":["10.1152\/ajpcell.1998.274.1.C105"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.1998.274.1.c105","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1,1]]}}}