{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:55:35Z","timestamp":1774659335280,"version":"3.50.1"},"reference-count":29,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[1998,8,1]]},"abstract":"<jats:p> l-Arginine (l-Arg) affects various parameters that modulate the progression of renal disease. These same factors [e.g., glomerular filtration rate, changes in mesangial cell (MC) tension, and production of NO] are all controlled at least in part by changes in MC intracellular Ca<jats:sup>2+<\/jats:sup>concentration ([Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>). We therefore evaluated the effect of l-Arg on MC [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>. We found thatl-Arg inhibits the vasopressin-stimulated rise in MC [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> both in rat and murine cell cultures. This effect does not appear to be due to metabolism of l-Arg to either NO or l-ornithine (l-Orn). Blocking the metabolism of l-Arg with N <jats:sup>\u03c9<\/jats:sup>-monomethyl-l-arginine, an NO synthase inhibitor, or with 20 mM l-valine (l-Val), an inhibitor of Orn formation, does not reverse the inhibition. However, other cationic amino acids, as well guanidine, the functional group ofl-Arg, all inhibit the vasopressin-stimulated rise in [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>, consistent with a structural basis for this effect. We conclude that 1)l-Arg inhibits vasopressin-stimulated murine and rat MC [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub>rise, 2) this inhibition is not mediated by metabolism of l-Arg to either NO or l-Orn, and 3) the effect ofl-Arg is due to its cationic functional group, guanidine. <\/jats:p>","DOI":"10.1152\/ajpcell.1998.275.2.c352","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T17:49:58Z","timestamp":1514137798000},"page":"C352-C357","source":"Crossref","is-referenced-by-count":65,"title":["<scp>l<\/scp>-Arginine inhibits vasopressin-stimulated  mesangial cell Ca<sup>2+<\/sup>"],"prefix":"10.1152","volume":"275","author":[{"given":"Leah","family":"Balsam","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Nassau County Medical Center, East Meadow 11554; and State University of New York, Stony Brook, New York 11794"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasrin","family":"Nikbakht","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, Nassau County Medical Center, East Meadow 11554; and State University of New York, Stony Brook, New York 11794"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112372"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI109723"},{"key":"B3","first-page":"A2112","volume":"7","author":"Balsam L.","year":"1996","journal-title":"J. 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