{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:56:38Z","timestamp":1774439798729,"version":"3.50.1"},"reference-count":26,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2000,1,1]]},"abstract":"<jats:p> The mechanism for cyanide (CN) activation of a nonselective cation (NS) channel coupled with a muscarinic receptor in a guinea pig chromaffin cell was studied with the perforated-patch method. Bath application of a protein kinase inhibitor resulted in a dose-dependent inhibition of muscarine-induced current ( I <jats:sub>M<\/jats:sub>) but had no apparent effect on the CN-induced current ( I <jats:sub>CN<\/jats:sub>). On the other hand, production of I <jats:sub>CN<\/jats:sub> occluded muscarine activation of NS channels in an amplitude-dependent manner. Deactivation of I <jats:sub>M<\/jats:sub> after washout was retarded while I <jats:sub>CN<\/jats:sub> was also active, and the extent of the retardation increased with an increase in the relative production of I <jats:sub>CN<\/jats:sub> on muscarinic stimulation. Restoration of Na<jats:sup>+<\/jats:sup> pump activity from CN suppression was conspicuously retarded below 19\u201320\u00b0C, and the apparent diminution of I <jats:sub>M<\/jats:sub> and I <jats:sub>CN<\/jats:sub> after washout was retarded in parallel with a decrease in temperature. The results suggest that CN activation of NS channels is due to suppression of deactivation of the channel. <\/jats:p>","DOI":"10.1152\/ajpcell.2000.278.1.c26","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T22:34:06Z","timestamp":1514154846000},"page":"C26-C32","source":"Crossref","is-referenced-by-count":3,"title":["Retardation of cation channel deactivation by mitochondrial  dysfunction in adrenal medullary cells"],"prefix":"10.1152","volume":"278","author":[{"given":"M.","family":"Inoue","sequence":"first","affiliation":[{"name":"Department of Physiology, School of Medicine, Fukuoka University, Fukuoka 814\u20130180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Fukuoka University, Fukuoka 814\u20130180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Imanaga","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Fukuoka University, Fukuoka 814\u20130180, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(86)90416-X"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1997.sp021890"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020143"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(99)77383-2"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.58.070189.002321"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198008213030806"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)43219-4"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019114"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019115"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-01-00063.1993"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.100.3.401"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1021\/bi00316a032"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.92.2.145"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.807bs.x"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.0385m.x"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.265.2.C343"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.105.2.249"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb13243.x"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018564"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s002329900143"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1992.tb08910.x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(96)10050-3"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020337"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.175bf.x"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1998.421be.x"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.21.10208"}],"container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.2000.278.1.C26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T19:06:19Z","timestamp":1718651179000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.2000.278.1.C26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1,1]]}},"alternative-id":["10.1152\/ajpcell.2000.278.1.C26"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.2000.278.1.c26","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1,1]]}}}