{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T16:12:08Z","timestamp":1789056728655,"version":"build-2803163510"},"reference-count":37,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[2008,8]]},"abstract":"<jats:p> Role of the intermediate filament protein desmin in hypertrophy of smooth muscle was examined in desmin-deficient mice (Des<jats:sup>\u2212\/\u2212<\/jats:sup>). A partial obstruction of the urethra was created, and after 9\u201319 days bladder weight increased approximately threefold in both Des<jats:sup>\u2212\/\u2212<\/jats:sup> and wild type (Des<jats:sup>+\/+<\/jats:sup>) animals. Bladder growth was associated with the synthesis of actin and myosin. In the hypertrophic Des<jats:sup>+\/+<\/jats:sup> bladder, the relative content of desmin increased. In Des<jats:sup>\u2212\/\u2212<\/jats:sup>mice, desmin was absent. No alterations in the amount of vimentin were observed. Although Des<jats:sup>\u2212\/\u2212<\/jats:sup> obstructed bladders were capable of growth, they had structural changes with a partial disruption of the wall. Des<jats:sup>\u2212\/\u2212<\/jats:sup>bladders had slightly lower passive stress and significantly lower active stress compared with Des<jats:sup>+\/+<\/jats:sup>. Des<jats:sup>\u2212\/\u2212<\/jats:sup>preparations had lower shortening velocity. During hypertrophy, these structural and mechanical alterations in the Des<jats:sup>\u2212\/\u2212<\/jats:sup>urinary bladder became more pronounced. In conclusion, desmin in the bladder smooth muscle is not needed for growth but has a role in active force transmission and maintenance of wall structure. <\/jats:p>","DOI":"10.1152\/ajpcell.90622.2007","type":"journal-article","created":{"date-parts":[[2008,6,19]],"date-time":"2008-06-19T00:54:45Z","timestamp":1213836885000},"page":"C324-C331","source":"Crossref","is-referenced-by-count":19,"title":["Role of desmin in active force transmission and maintenance of structure during growth of urinary bladder"],"prefix":"10.1152","volume":"295","author":[{"given":"R. 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