{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:30:47Z","timestamp":1790519447544,"version":"4.1.0"},"reference-count":14,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["R01 DK-40936"],"award-info":[{"award-number":["R01 DK-40936"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["P30 DK-45735"],"award-info":[{"award-number":["P30 DK-45735"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["T32 DK-101019"],"award-info":[{"award-number":["T32 DK-101019"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["R01 DK-92606"],"award-info":[{"award-number":["R01 DK-92606"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)","doi-asserted-by":"publisher","award":["U24 DK-59635"],"award-info":[{"award-number":["U24 DK-59635"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging (U.S. National Institute on Aging)","doi-asserted-by":"publisher","award":["R01 AG-23686"],"award-info":[{"award-number":["R01 AG-23686"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2016,8,1]]},"abstract":"<jats:p>Imeglimin is a promising new oral antihyperglycemic agent that has been studied in clinical trials as a possible monotherapy or add-on therapy to lower fasting plasma glucose and improve hemoglobin A<jats:sub>1c<\/jats:sub>(1\u20133, 9). Imeglimin was shown to improve both fasting and postprandial glycemia and to increase insulin secretion in response to glucose during a hyperglycemic clamp after 1-wk of treatment in type 2 diabetic patients. However, whether the \u03b2-cell stimulatory effect of imeglimin is solely or partially responsible for its effects on glycemia remains to be fully confirmed. Here, we show that imeglimin directly activates \u03b2-cell insulin secretion in awake rodents without affecting hepatic insulin sensitivity, body composition, or energy expenditure. These data identify a primary amplification rather than trigger the \u03b2-cell mechanism that explains the acute, antidiabetic activity of imeglimin.<\/jats:p>","DOI":"10.1152\/ajpendo.00009.2016","type":"journal-article","created":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T02:34:08Z","timestamp":1468377248000},"page":"E461-E470","source":"Crossref","is-referenced-by-count":69,"title":["Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents"],"prefix":"10.1152","volume":"311","author":[{"given":"Rachel J.","family":"Perry","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Cardone","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max C.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and"},{"name":"Cellular and Molecular Physiology and"},{"name":"Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascale","family":"Fouqueray","sequence":"additional","affiliation":[{"name":"Poxel SA, Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Hallakou-Bozec","sequence":"additional","affiliation":[{"name":"Poxel SA, Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Bolze","sequence":"additional","affiliation":[{"name":"Poxel SA, Paris, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald I.","family":"Shulman","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and"},{"name":"Cellular and Molecular Physiology and"},{"name":"Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut;"},{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kitt Falk","family":"Petersen","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and"},{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard G.","family":"Kibbey","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine and"},{"name":"Cellular and Molecular Physiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.4172\/2155-6156.1000126"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2349"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0453"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.6.1270"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8227(11)70010-9"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.11.1751"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1685-0"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12452"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01611.x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112981"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.011775"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.2337\/db14-1220"},{"key":"B13","doi-asserted-by":"crossref","first-page":"2864","DOI":"10.1016\/S0021-9258(19)50663-9","volume":"267","author":"Witters LA","year":"1992","journal-title":"J Biol Chem"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.03.012"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00009.2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T01:00:16Z","timestamp":1656810016000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpendo.00009.2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,1]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,8,1]]}},"alternative-id":["10.1152\/ajpendo.00009.2016"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00009.2016","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,1]]}}}