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Fasting blood glucose levels were significantly elevated in 8-wk-old CMV-binding protein (CMVBP)-3- and PGK binding protein (PGKBP)-3-Tg mice compared with Wt mice: 6.35 \u00b1 0.22 and 5.22 \u00b1 0.39 vs. 3.99 \u00b1 0.26 mmol\/l, respectively. Plasma insulin was significantly elevated only in CMVBP-3-Tg mice. The responses to a glucose challenge were significantly increased in both Tg strains: area under the glucose curve = 1,824 \u00b1 65 and 1,910 \u00b1 115 vs. 1,590 \u00b1 67 mmol \u00b7 l<jats:sup>\u22121<\/jats:sup>\u00b7 min for CMVBP-3, PGKBP-3, and Wt mice, respectively. The hypoglycemic effects of insulin and IGF-I were significantly attenuated in Tg mice compared with Wt mice. There were no differences in adipose tissue resistin, retinoid X receptor-\u03b1, or peroxisome proliferator-activated receptor-\u03b3 mRNA levels between Tg and Wt mice. Uptake of 2-deoxyglucose was reduced in muscle and adipose tissue from Tg mice compared with Wt mice. These data demonstrate that overexpression of hIGFBP-3 results in fasting hyperglycemia, impaired glucose tolerance, and insulin resistance.<\/jats:p>","DOI":"10.1152\/ajpendo.00014.2002","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T19:50:01Z","timestamp":1425412201000},"page":"E937-E945","source":"Crossref","is-referenced-by-count":76,"title":["Impaired glucose homeostasis in insulin-like growth factor-binding protein-3-transgenic mice"],"prefix":"10.1152","volume":"283","author":[{"given":"Josef V.","family":"Silha","sequence":"first","affiliation":[{"name":"Departments of Physiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoting","family":"Gui","sequence":"additional","affiliation":[{"name":"Departments of Physiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liam J.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Departments of Physiology and"},{"name":"Internal Medicine, University of Manitoba, Winnipeg R3E 0W3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(93)90342-6"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114072"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1159\/000184186"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(66)90124-3"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90478-U"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.2302"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.17.6778"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.277.2.E245"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/19.22.6205"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.1210753"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.40.25252"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1210\/endo.136.11.7588232"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1210\/endo-129-4-2254"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002547200"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.5.8165"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.12.3116S"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4684-5949-4_14"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/0955-2235(95)00025-9"},{"key":"B19","doi-asserted-by":"crossref","first-page":"26045","DOI":"10.1016\/S0021-9258(19)74273-2","volume":"268","author":"Oh Y","year":"1993","journal-title":"J Biol Chem"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118982"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-2988-0_30"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M002208200"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.12.7088"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.7.1539"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/35053000"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1210\/endo-104-6-1733"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90011-M"},{"key":"B28","first-page":"361","volume":"9","author":"Valentinis B","year":"1995","journal-title":"Mol Endocrinol"},{"key":"B29","first-page":"A268","volume":"50","author":"Vuguin PM","year":"2001","journal-title":"Diabetes"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.5.1110"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.13.7324"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1159\/000184139"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00014.2002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T08:46:56Z","timestamp":1651394816000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpendo.00014.2002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11,1]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,11,1]]}},"alternative-id":["10.1152\/ajpendo.00014.2002"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00014.2002","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11,1]]}}}