{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:08:26Z","timestamp":1790906906386,"version":"4.1.0"},"reference-count":56,"publisher":"American Physiological Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2014,12,15]]},"abstract":"<jats:p> Increased skeletal muscle capillarization is associated with improved glucose tolerance and insulin sensitivity. However, a possible causal relationship has not previously been identified. Therefore, we investigated whether increased skeletal muscle capillarization increases insulin sensitivity. Skeletal muscle-specific angiogenesis was induced by adding the \u03b1<jats:sub>1<\/jats:sub>-adrenergic receptor antagonist prazosin to the drinking water of Sprague-Dawley rats ( n = 33), whereas 34 rats served as controls. Insulin sensitivity was measured \u226540 h after termination of the 3-wk prazosin treatment, which ensured that prazosin was cleared from the blood stream. Whole body insulin sensitivity was measured in conscious, unrestrained rats by hyperinsulinemic euglycemic clamp. Tissue-specific insulin sensitivity was assessed by administration of 2-deoxy-[<jats:sup>3<\/jats:sup>H]glucose during the plateau phase of the clamp. Whole body insulin sensitivity increased by \u223c24%, and insulin-stimulated skeletal muscle 2-deoxy-[<jats:sup>3<\/jats:sup>H]glucose disposal increased by \u223c30% concomitant with an \u223c20% increase in skeletal muscle capillarization. Adipose tissue insulin sensitivity was not affected by the treatment. Insulin-stimulated muscle glucose uptake was enhanced independent of improvements in skeletal muscle insulin signaling to glucose uptake and glycogen synthesis, suggesting that the improvement in insulin-stimulated muscle glucose uptake could be due to improved diffusion conditions for glucose in the muscle. The prazosin treatment did not affect the rats on any other parameters measured. We conclude that an increase in skeletal muscle capillarization is associated with increased insulin sensitivity. These data point toward the importance of increasing skeletal muscle capillarization for prevention or treatment of type 2 diabetes. <\/jats:p>","DOI":"10.1152\/ajpendo.00020.2014","type":"journal-article","created":{"date-parts":[[2014,10,29]],"date-time":"2014-10-29T06:30:39Z","timestamp":1414564239000},"page":"E1105-E1116","source":"Crossref","is-referenced-by-count":49,"title":["Increased skeletal muscle capillarization enhances insulin sensitivity"],"prefix":"10.1152","volume":"307","author":[{"given":"Thorbjorn","family":"Akerstrom","sequence":"first","affiliation":[{"name":"Section of Integrative Physiology, Department of Nutrition, Exercise, and Sports, The August Krogh Centre, University of Copenhagen, Copenhagen, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse","family":"Laub","sequence":"additional","affiliation":[{"name":"Section of Integrative Physiology, Department of Nutrition, Exercise, and Sports, The August Krogh Centre, University of Copenhagen, Copenhagen, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Vedel","sequence":"additional","affiliation":[{"name":"Section of Integrative Physiology, Department of Nutrition, Exercise, and Sports, The August Krogh Centre, University of Copenhagen, Copenhagen, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Lehn","family":"Brand","sequence":"additional","affiliation":[{"name":"Clamp Competency Center, Novo Nordisk, Maaloev, Denmark; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente Klarlund","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Centre of Inflammation and Metabolism at the Department of Infectious Diseases and Copenhagen Muscle Research Centre, Rigshospitalet and Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Kaufmann","family":"Lindqvist","sequence":"additional","affiliation":[{"name":"Section of Integrative Physiology, Department of Nutrition, Exercise, and Sports, The August Krogh Centre, University of Copenhagen, Copenhagen, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen F. 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