{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T23:34:28Z","timestamp":1776900868805,"version":"3.51.2"},"reference-count":21,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100012166","name":"MOST | National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2500600 and 2021YFC2500603"],"award-info":[{"award-number":["2021YFC2500600 and 2021YFC2500603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"MOST | National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270737"],"award-info":[{"award-number":["32270737"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:p> In this first metabolic phenotype study of Ahdc1 deficiency, we generated a survivable Ahdc1-deficient mouse line. We found that Ahdc1 deficiency in both male and female mice resulted in adiposity from weaning and obesity characterized by reduced energy expenditure and respiratory quotient. Additionally, there was a progressive development of hyperleptinemia, insulin resistance, abnormal glycolipid metabolism, and fatty liver. These findings demonstrate that Ahdc1 is a novel key regulator of obesity and energy metabolism. <\/jats:p>","DOI":"10.1152\/ajpendo.00048.2023","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T13:44:48Z","timestamp":1697031888000},"page":"E638-E648","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Ahdc1 is a potent regulator of obesity and energy metabolism"],"prefix":"10.1152","volume":"325","author":[{"given":"Linyi","family":"Li","sequence":"first","affiliation":[{"name":"Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shipeng","family":"Shao","sequence":"additional","affiliation":[{"name":"Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyong","family":"Du","sequence":"additional","affiliation":[{"name":"Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huahui","family":"Yu","sequence":"additional","affiliation":[{"name":"Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5185-9726","authenticated-orcid":false,"given":"Yanwen","family":"Qin","sequence":"additional","affiliation":[{"name":"Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-021-00414-z"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xhgg.2021.100049"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1101\/mcs.a000562"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.04.006"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/humu.24190"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.10.026"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04727-9"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0269077"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-022-01149-5"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.596"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3343\/alm.2017.37.6.563"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.2058"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5907361"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000360"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioaa144"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2013.055"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.12.012"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665121003761"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12787"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-022-00741-z"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00397.2011"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00048.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T15:08:19Z","timestamp":1700060899000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00048.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,11,1]]}},"alternative-id":["10.1152\/ajpendo.00048.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00048.2023","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,1]]},"assertion":[{"value":"2023-02-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-28","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}