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Compared with controls, HLS patients had lower fat mass (15.9 \u00b1 1.3 vs. 22.3 \u00b1 1.7 kg, P &lt; 0.05) but higher plasma glycerol rate of appearance (R<jats:sub>a<\/jats:sub>), an index of total lipolysis (964.71 \u00b1 103.33 vs. 611.08 \u00b1 63.38 \u03bcmol \u00b7 kg fat<jats:sup>\u22121<\/jats:sup>\u00b7 h<jats:sup>\u22121<\/jats:sup>, P &lt; 0.05), R<jats:sub>a<\/jats:sub>palmitate, an index of net lipolysis (731.49 \u00b1 72.36 vs. 419.72 \u00b1 33.78 \u03bcmol \u00b7 kg fat<jats:sup>\u22121<\/jats:sup>\u00b7 h<jats:sup>\u22121<\/jats:sup>, P &lt; 0.01), R<jats:sub>a<\/jats:sub>free fatty acids (2,094.74 \u00b1 182.18 vs. 1,470.87 \u00b1 202.80 \u03bcmol \u00b7 kg fat<jats:sup>\u22121<\/jats:sup>\u00b7 h<jats:sup>\u22121<\/jats:sup>, P &lt; 0.05), and rates of intra-adipocyte (799.40 \u00b1 157.69 vs. 362.36 \u00b1 74.87 \u03bcmol \u00b7 kg fat<jats:sup>\u22121<\/jats:sup>\u00b7 h<jats:sup>\u22121<\/jats:sup>, P &lt; 0.01) and intrahepatic fatty acid reesterification (1,352.08 \u00b1 123.90 vs. 955.56 \u00b1 124.09 \u03bcmol \u00b7 kg fat<jats:sup>\u22121<\/jats:sup>\u00b7 h<jats:sup>\u22121<\/jats:sup>, P &lt; 0.05). Resting energy expenditure was increased in HLS patients (30.51 \u00b1 2.53 vs. 25.34 \u00b1 1.04 kcal \u00b7 kg lean body mass<jats:sup>\u22121<\/jats:sup>\u00b7 day<jats:sup>\u22121<\/jats:sup>, P &lt; 0.05), associated with increased non-plasma-derived fatty acid oxidation (139.04 \u00b1 24.17 vs. 47.87 \u00b1 18.81 \u03bcmol \u00b7 kg lean body mass<jats:sup>\u22121<\/jats:sup>\u00b7 min<jats:sup>\u22121<\/jats:sup>, P &lt; 0.02). The lipoatrophy observed in HIV lipodystrophy is associated with accelerated lipolysis. Increased hepatic reesterification promotes the hypertriglyceridemia observed in this syndrome.<\/jats:p>","DOI":"10.1152\/ajpendo.00058.2002","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T20:10:55Z","timestamp":1425067855000},"page":"E332-E337","source":"Crossref","is-referenced-by-count":101,"title":["Metabolic basis of HIV-lipodystrophy syndrome"],"prefix":"10.1152","volume":"283","author":[{"given":"Rajagopal V.","family":"Sekhar","sequence":"first","affiliation":[{"name":"Sections of Endocrinology,"},{"name":"Department of Pediatrics, Children's Nutrition Research Center and US Department of Agriculture\/Agricultural Research Service, Baylor College of Medicine, Houston 77030; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farook","family":"Jahoor","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Children's Nutrition Research Center and US Department of Agriculture\/Agricultural Research Service, Baylor College of Medicine, Houston 77030; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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