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To this end, we deconvolved 24-h serum concentrations of LH and FSH in seven hypocretin-deficient narcoleptic males (N) and seven controls (C) matched for age, body mass index, and sex. Basal plasma concentrations of testosterone, estradiol, and sex hormone-binding globulin were similar in both groups. Mean 24-h LH concentration was significantly lower in narcolepsy patients [3.0 \u00b1 0.4 (N) vs. 4.2 \u00b1 0.3 (C) U\/l, P = 0.01], which was primarily due to a reduction of pulsatile LH secretion [23.5 \u00b1 1.6 (N) vs. 34.3 \u00b1 4.9 (C) U\u00b7l<jats:sup>\u22121<\/jats:sup>\u00b724 h<jats:sup>\u22121<\/jats:sup>, P = 0.02]. The orderliness of LH and FSH secretion, quantitated by the approximate entropy statistic, was greater in patients than in controls. In contrast, all other features of FSH release were similar in narcoleptic and control groups. Also, LH and FSH secretions in response to intravenous administration of 100 \u03bcg of GnRH were similar in patients and controls. These data indicate that endogenous hypocretins are involved in the regulation of the hypothalamo-pituitary-gonadal axis activity in humans. In particular, reduced LH release in the face of normal pituitary responsivity to GnRH stimulation in narcoleptic men suggests that hypocretins promote endogenous GnRH secretion. <\/jats:p>","DOI":"10.1152\/ajpendo.00060.2004","type":"journal-article","created":{"date-parts":[[2004,6,8]],"date-time":"2004-06-08T00:18:21Z","timestamp":1086653901000},"page":"E630-E636","source":"Crossref","is-referenced-by-count":51,"title":["Pulsatile LH release is diminished, whereas FSH secretion is normal, in hypocretin-deficient narcoleptic men"],"prefix":"10.1152","volume":"287","author":[{"given":"S. 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