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When uremic rats adapted to a high P<jats:sub>i<\/jats:sub> diet (HPD) were fed a single meal of low P<jats:sub>i<\/jats:sub> diet (LPD), plasma PTH fell 80% within 2 h; plasma P<jats:sub>i<\/jats:sub> fell 1 mg\/dl with no change in plasma ionized Ca (ICa). When uremic rats on the HPD were gavaged with LPD, PTH fell 60% within 15 min; plasma P<jats:sub>i<\/jats:sub> fell by 3.0 mg\/dl with no change in total plasma Ca. However, HPD gavage increased PTH by 80% within 15 min with no change in plasma P or Ca, suggesting that the response may be independent of altered plasma P<jats:sub>i<\/jats:sub>. Duodenal infusion of sodium P<jats:sub>i<\/jats:sub> increased PTH twofold within 10 min, with no change in ICa but an increase in plasma P<jats:sub>i<\/jats:sub>, whereas duodenal infusion of NaCl had no effect on any of these parameters. Intravenous infusion of sodium phosphate also increased PTH within 10 min with no change in plasma ICa; intravenous NaCl had no effect. Additionally, duodenal infusion of phosphonoformate, a nonabsorbable phosphate analog, increased PTH fourfold within 5 min, but did not change plasma P or ICa. These findings indicate that oral P<jats:sub>i<\/jats:sub> increases PTH release in vivo more rapidly than previously reported; this response may be from both plasma phosphate and an additional signal arising from the gastrointestinal tract. <\/jats:p>","DOI":"10.1152\/ajpendo.00065.2005","type":"journal-article","created":{"date-parts":[[2005,5,25]],"date-time":"2005-05-25T02:28:53Z","timestamp":1116988133000},"page":"E729-E734","source":"Crossref","is-referenced-by-count":64,"title":["Acute regulation of parathyroid hormone by dietary phosphate"],"prefix":"10.1152","volume":"289","author":[{"given":"Daniel R.","family":"Martin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia S.","family":"Ritter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Slatopolsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex J.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650110714"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1985.249.1.C140"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00386.x"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(84)90332-8"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1007\/BF00581243"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1985.248.1.F122"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.00933.x"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.00042.x"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(96)90473-4"},{"key":"R10","doi-asserted-by":"crossref","unstructured":"Farnebo F, Enberg U, Grimelius L, Backdahl M, Schalling M, Larsson C, and Farnebo LO. 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