{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:17:45Z","timestamp":1785421065418,"version":"3.56.0"},"reference-count":31,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000069","name":"HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["AR076146"],"award-info":[{"award-number":["AR076146"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX002490-06A1"],"award-info":[{"award-number":["BX002490-06A1"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2025,11,1]]},"abstract":"<jats:p>\n                    This is the first study to assess directly the effects of very low concentrations of ACTH\n                    <jats:sub>1\u201324<\/jats:sub>\n                    , picomolar to micromolar, on regulation of bone growth. It shows effects on bone mass in the femoral heads and by labeling bone formation in rabbits in vitro, and effect on key proteins related to bone growth mechanisms in cell preparations of human bone-forming cells in vitro.\n                  <\/jats:p>","DOI":"10.1152\/ajpendo.00084.2025","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T17:20:46Z","timestamp":1757697646000},"page":"E707-E718","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Concentrations of adrenocorticotropic hormone too low to effect cortisol enhance osteogenesis in vitro and in vivo"],"prefix":"10.1152","volume":"329","author":[{"given":"Irina L.","family":"Tourkova","sequence":"first","affiliation":[{"name":"Pittsburgh Veterans Affairs Medical Center","place":["United States"]},{"id":[{"id":"https:\/\/ror.org\/01an3r305","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pittsburgh","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reed A.","family":"Rankin","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01an3r305","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pittsburgh","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6532-9315","authenticated-orcid":false,"given":"Quitterie C.","family":"Larrouture","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01an3r305","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pittsburgh","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven F.","family":"Dobrowolski","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01an3r305","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pittsburgh","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4480-3484","authenticated-orcid":false,"given":"Carlos M.","family":"Isales","sequence":"additional","affiliation":[{"name":"Georgia Medical College at Augusta University","place":["United States"]},{"name":"Georgia Medical College at Augusta University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1152-3718","authenticated-orcid":false,"given":"Harry C.","family":"Blair","sequence":"additional","affiliation":[{"name":"Pittsburgh Veterans Affairs Medical Center","place":["United States"]},{"id":[{"id":"https:\/\/ror.org\/01an3r305","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Pittsburgh","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.05231.x"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076840"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnad025"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-023-06809-4"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2013.09.006"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S17521"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.15330"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912176107"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2017.62"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jds.2015.07.001"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2021.09.075"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30494"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.02.112"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-0716-1028-2_15"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2021.01.014"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00227.2023"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2015.03.001"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-019-0311-0"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040894"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009787"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24983"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-98625-1"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-68566-2"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgmr.2023.100996"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2022.03.012"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2022.116371"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.05.044"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2016.05.015"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.593310"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.10.1842"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10051"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00084.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:29:48Z","timestamp":1763749788000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00084.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,1]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,11,1]]}},"alternative-id":["10.1152\/ajpendo.00084.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00084.2025","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,1]]},"assertion":[{"value":"2025-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}