{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T09:33:26Z","timestamp":1794044006910,"version":"4.8.0"},"reference-count":56,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100031376","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Rhumatologie","doi-asserted-by":"publisher","award":["2020-2650"],"award-info":[{"award-number":["2020-2650"]}],"id":[{"id":"10.13039\/100031376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["220271\/Z\/20\/Z"],"award-info":[{"award-number":["220271\/Z\/20\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UKRI | Medical Research Council","doi-asserted-by":"publisher","award":["MRC_MC_UU_12012\/3"],"award-info":[{"award-number":["MRC_MC_UU_12012\/3"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:p> This study discovered that medications mimicking GLP-1, like exendin-4, improve bone strength and structure in mice, including better bone volume and collagen quality. Interestingly, exendin-4\u2019s effects were observed when delivered to the brain but not when prevented from reaching it. This suggests GLP-1 influences bones through brain signals rather than acting directly on bone. Although GLP-1 treatments show promise for preventing bone weakness, more research is needed to understand this brain-bone connection. <\/jats:p>","DOI":"10.1152\/ajpendo.00086.2025","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T01:20:37Z","timestamp":1754961637000},"page":"E522-E536","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["The GLP-1 analog, exendin-4, improves bone material properties and strength through a central relay in ovariectomized mice"],"prefix":"10.1152","volume":"329","author":[{"given":"Morgane","family":"Mermet","sequence":"first","affiliation":[{"name":"Univ Angers, Nantes Universit\u00e9, ONIRIS, Inserm, SFR ICAT","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Denom","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Mieczkowska","sequence":"additional","affiliation":[{"name":"Univ Angers, Nantes Universit\u00e9, ONIRIS, Inserm, SFR ICAT","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9line","family":"Wery","sequence":"additional","affiliation":[{"name":"Univ Angers","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Biggs","sequence":"additional","affiliation":[{"name":"University of Cambridge","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4232-2898","authenticated-orcid":false,"given":"Fiona M.","family":"Gribble","sequence":"additional","affiliation":[{"name":"University of Cambridge","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9399-6377","authenticated-orcid":false,"given":"Frank","family":"Reimann","sequence":"additional","affiliation":[{"name":"University of Cambridge","place":["United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7044-2571","authenticated-orcid":false,"given":"Christophe","family":"Magnan","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2562-5360","authenticated-orcid":false,"given":"C\u00e9line","family":"Cruciani-Guglielmacci","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1445-329X","authenticated-orcid":false,"given":"Guillaume","family":"Mabilleau","sequence":"additional","affiliation":[{"name":"Univ Angers, Nantes Universit\u00e9, ONIRIS, Inserm, SFR ICAT","place":["France"]},{"name":"CHU Angers","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s11657-020-00871-9"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067312"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607948"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809493"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-024-01000-z"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-13-0146"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-1292"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.21037\/apm-19-396"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2019-00008"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00781"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14568"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1002\/jbm4.10209"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-024-00979-9"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0132744"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1898"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25033"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-018-0507-0"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-020-00720-4"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00327"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.08.006"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12102"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3168"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-18-0214"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.721506"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1937"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.050307"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4792"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.06.024"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0281"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0121"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.141"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bonr.2020.100251"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1805"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2539"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-023-01105-z"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1440"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019170"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802138200"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.07.014"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1934"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2015.07.008"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-51076-4"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-05323-7"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1126\/science.adt0548"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2014.1787"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22243"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1272"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81558-5"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00014.2017"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.09.025"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802206"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:18:1-2:07"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2022.106022"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.133429"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-13-33"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2023.109637"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00086.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T13:42:50Z","timestamp":1761054170000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00086.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10,1]]}},"alternative-id":["10.1152\/ajpendo.00086.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00086.2025","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"assertion":[{"value":"2025-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-20","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}