{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:08:23Z","timestamp":1790086103447,"version":"4.0.1"},"reference-count":84,"publisher":"American Physiological Society","issue":"4","funder":[{"name":"departmental research funding"}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>This study uniquely examined how ghrelin deficiency interacts with prepubertal chronic DHT exposure, a PMOS mouse model, shaping metabolism and eating behavior in female mice. Although ghrelin deficiency minimally altered DHT-induced reproductive or metabolic phenotypes, chronic DHT exposure affected behavioral responses to acute ghrelin, indicating interacting mechanisms between androgen and ghrelin signaling in PMOS. This work highlights the importance of detailed behavioral assessment of translational models of disease to explore mechanisms behind aberrant behavior.<\/jats:p>","DOI":"10.1152\/ajpendo.00108.2026","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:54:28Z","timestamp":1788562468000},"page":"E479-E490","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced behavioral responses to ghrelin administration are unaffected by ghrelin deficiency in a DHT-induced PCOS mouse model"],"prefix":"10.1152","volume":"331","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-3238","authenticated-orcid":false,"given":"Karina","family":"Prins","sequence":"first","affiliation":[{"name":"University Medical Center","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Meng","sequence":"additional","affiliation":[{"name":"University Medical Center","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"McLuskey","sequence":"additional","affiliation":[{"name":"University Medical Center","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Huisman","sequence":"additional","affiliation":[{"name":"University Medical Center","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobie","family":"Steenbergen","sequence":"additional","affiliation":[{"name":"University Medical Center","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0828-3143","authenticated-orcid":false,"given":"Patric J. D.","family":"Delhanty","sequence":"additional","affiliation":[{"name":"University Medical Center","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7182-3571","authenticated-orcid":false,"given":"Jenny A.","family":"Visser","sequence":"additional","affiliation":[{"name":"University Medical Center","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/45230"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.12.8111"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1978"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.8.1714"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/35038090"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.11.7873"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-015-9685-y"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29867"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1159\/000054491"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.075291"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.10.8098"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0271"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2011.07.003"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.04.004"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.358051"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021169"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41387-018-0048-7"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031412"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12764"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02768.x"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0783"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2016"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030554"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.901669"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00432.2021"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-20-0579"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2009.06.010"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2018.05.012"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04010-3"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2011.12.016"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(26)00717-8"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.05.003"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2022.10.020"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmad015"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2016.12.014"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2015.02.006"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14153"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms030"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.2337\/diab.38.9.1165"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq001"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqac164"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1159\/000521236"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158207"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1754"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ15-0318"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2018.1534096"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/bf03347020"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031583"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26003"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00321.2007"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1616467114"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3791\/4389"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0556"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod57.5.1233"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.115.136515"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00946"},{"key":"B57","doi-asserted-by":"crossref","unstructured":"Kassambara A. rstatix: Pipe-Friendly Framework for Basic Statistical Tests. R package version 0.6.0. 2020.","DOI":"10.32614\/CRAN.package.rstatix"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvab060"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2021.105776"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.12.023"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1080\/03630242.2022.2106529"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2014.984677"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1186\/s40337-022-00593-y"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.11.067"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00181.2005"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2011.02126.x"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13370"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402763101"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.754522"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12327"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1080\/09513590701507817"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh122"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1530\/joe-24-0348"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.00531"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3390\/nu14010073"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmac023"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-19-0213"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-1600.2006.00002.x"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.03.049"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2016.11.005"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2012.01.025"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.86454"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202401772"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1038\/srep02116"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00108.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:50:43Z","timestamp":1790085043000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00108.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":84,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10,1]]}},"alternative-id":["10.1152\/ajpendo.00108.2026"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00108.2026","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"assertion":[{"value":"2026-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-06","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}