{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T13:46:36Z","timestamp":1780580796179,"version":"3.54.1"},"reference-count":52,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p> Fetal growth restriction is associated with reduced pancreatic \u03b2-cell mass, contributing to impaired glucose tolerance and diabetes. Exercise training increases \u03b2-cell mass in animals with diabetes and has long-lasting metabolic benefits in rodents and humans. We studied the effect of exercise training on islet and \u03b2-cell morphology and plasma insulin and glucose, following an intraperitoneal glucose tolerance test (IPGTT) in juvenile and adult male Wistar-Kyoto rats born small. Bilateral uterine vessel ligation performed on day 18 of pregnancy resulted in Restricted offspring born small compared with sham-operated Controls and also sham-operated Reduced litter offspring that had their litter size reduced to five pups at birth. Restricted, Control, and Reduced litter offspring remained sedentary or underwent treadmill running from 5 to 9 or 20 to 24 wk of age. Early life exercise increased relative islet surface area and \u03b2-cell mass across all groups at 9 wk, partially restoring the 60\u201368% deficit ( P &lt; 0.05) in Restricted offspring. Remarkably, despite no further exercise training after 9 wk, \u03b2-cell mass was restored in Restricted at 24 wk, while sedentary littermates retained a 45% deficit ( P = 0.05) in relative \u03b2-cell mass. Later exercise training also restored Restricted \u03b2-cell mass to Control levels. In conclusion, early life exercise training in rats born small restored \u03b2-cell mass in adulthood and may have beneficial consequences for later metabolic health and disease. <\/jats:p>","DOI":"10.1152\/ajpendo.00114.2011","type":"journal-article","created":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T22:30:36Z","timestamp":1312324236000},"page":"E931-E940","source":"Crossref","is-referenced-by-count":47,"title":["Short-term exercise training early in life restores deficits in pancreatic \u03b2-cell mass associated with growth restriction in adult male rats"],"prefix":"10.1152","volume":"301","author":[{"given":"Rhianna C.","family":"Laker","sequence":"first","affiliation":[{"name":"Department of Physiology, The University of Melbourne, Parkville, Victoria, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A.","family":"Gallo","sequence":"additional","affiliation":[{"name":"Department of Physiology, The University of Melbourne, Parkville, 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