{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:31:05Z","timestamp":1767857465400,"version":"3.49.0"},"reference-count":33,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2002,12,1]]},"abstract":"<jats:p>The progesterone receptor (PR) has three isoforms, PR-A, PR-B, and PR-C, which have different physiological effects. PR-A may inhibit PR-B-mediated transcription. Parturition requires withdrawal of progesterone (P<jats:sub>4<\/jats:sub>). This could occur through decreased P<jats:sub>4<\/jats:sub>concentrations and\/or a change in PR isoforms to diminish the effect of P<jats:sub>4<\/jats:sub>. We measured mRNA for PR isoforms in rat uterine tissues through late gestation and investigated the effects of antagonists to estrogen (tamoxifen) and P<jats:sub>4<\/jats:sub>(RU-486). Two specific probes were used for ribonuclease protection assays; one (PR-total) measured PR-A, PR-B, and PR-C, and the other recognized only PR-B. PR-total mRNA increased significantly through late gestation, whereas PR-B was unchanged. The ratio of PR-total to PR-B peaked on the day before parturition. Tamoxifen delayed parturition and inhibited the increase in PR-total without affecting PR-B mRNA. RU-486 caused early parturition associated with increased PR-total mRNA, with no change in PR-B. We conclude that there are significant changes in PR isoforms in late-gestation rat uterus. These changes may be regulated by estrogen and P<jats:sub>4<\/jats:sub>and may influence the timing of parturition.<\/jats:p>","DOI":"10.1152\/ajpendo.00116.2002","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T20:14:36Z","timestamp":1425068076000},"page":"E1167-E1172","source":"Crossref","is-referenced-by-count":16,"title":["Messenger RNA for progesterone receptor isoforms in the late-gestation rat uterus"],"prefix":"10.1152","volume":"283","author":[{"given":"X.","family":"Fang","sequence":"first","affiliation":[{"name":"Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Wong","sequence":"additional","affiliation":[{"name":"Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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