{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:47:03Z","timestamp":1792691223964,"version":"4.5.0"},"reference-count":50,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p>Hypertriglyceridemia is common in individuals with human immunodeficiency (HIV) infection, but the mechanisms responsible for increased plasma triglyceride (TG) concentrations are not clear. We evaluated fatty acid and VLDL-TG kinetics during basal conditions and during a glucose infusion that resulted in typical postprandial plasma glucose and insulin concentrations in six men with HIV-dyslipidemia [body mass index (BMI): 28 \u00b1 2 kg\/m<jats:sup>2<\/jats:sup>] and six healthy men (BMI: 26 \u00b1 2 kg\/m<jats:sup>2<\/jats:sup>). VLDL-TG secretion and palmitate rate of appearance (R<jats:sub>a<\/jats:sub>) in plasma were measured by using stable-isotope-labeled tracer techniques. Basal palmitate R<jats:sub>a<\/jats:sub>and VLDL-TG secretion rates were greater ( P &lt; 0.01 for both) in men with HIV-dyslipidemia (1.04 \u00b1 0.07 \u03bcmol palmitate \u00b7 kg<jats:sup>-<\/jats:sup><jats:sup>1<\/jats:sup>\u00b7 min<jats:sup>-<\/jats:sup><jats:sup>1<\/jats:sup>and 5.7 \u00b1 0.6 \u03bcmol VLDL-TG \u00b7 l plasma<jats:sup>-<\/jats:sup><jats:sup>1<\/jats:sup>\u00b7 min<jats:sup>-<\/jats:sup><jats:sup>1<\/jats:sup>) than in healthy men (0.67 \u00b1 0.08 \u03bcmol palmitate \u00b7 kg<jats:sup>-<\/jats:sup><jats:sup>1<\/jats:sup>\u00b7 min<jats:sup>-<\/jats:sup><jats:sup>1<\/jats:sup>and 3.0 \u00b1 0.5 \u03bcmol VLDL-TG \u00b7 l plasma<jats:sup>-<\/jats:sup><jats:sup>1<\/jats:sup>\u00b7 min<jats:sup>-<\/jats:sup><jats:sup>1<\/jats:sup>). Basal VLDL-TG plasma clearance was lower in men with HIV-dyslipidemia (13 \u00b1 1 ml\/min) than in healthy men (19 \u00b1 2 ml\/min; P &lt; 0.05). Glucose infusion decreased palmitate R<jats:sub>a<\/jats:sub>(by \u223c50%) and the VLDL-TG secretion rate (by \u223c30%) in both groups, but the VLDL-TG secretion rate remained higher ( P &lt; 0.05) in subjects with HIV-dyslipidemia. These findings demonstrate that increased secretion of VLDL-TG and decreased plasma VLDL-TG clearance, during both fasting and fed conditions, contribute to hypertriglyceridemia in men with HIV-dyslipidemia. Although it is likely that increased free fatty acid release from adipose tissue contributes to the increase in basal VLDL-TG concentration, other factors must be involved, because insulin-induced suppression of lipolysis and systemic fatty acid availability did not normalize the VLDL-TG secretion rate.<\/jats:p>","DOI":"10.1152\/ajpendo.00118.2003","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T19:52:43Z","timestamp":1425412363000},"page":"E490-E497","source":"Crossref","is-referenced-by-count":76,"title":["Alterations in lipid kinetics in men with HIV-dyslipidemia"],"prefix":"10.1152","volume":"285","author":[{"given":"D. N.","family":"Reeds","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Mittendorfer","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. W.","family":"Patterson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. G.","family":"Powderly","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. E.","family":"Yarasheski","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"REF1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119005"},{"key":"REF2","doi-asserted-by":"publisher","DOI":"10.3109\/07853899709002451"},{"key":"REF3","unstructured":"Austin MA.Plasma triglyceride as a risk factor for cardiovascular disease.Can J Cardiol14,SupplB: 14B-17B, 1998."},{"key":"REF4","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200102160-00016"},{"key":"REF5","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199907090-00001"},{"key":"REF6","doi-asserted-by":"publisher","DOI":"10.2310\/6650.2001.34108"},{"key":"REF7","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1984.247.4.F632"},{"key":"REF8","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199807000-00003"},{"key":"REF9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)08468-2"},{"key":"REF10","unstructured":"Castelli WP.Cholesterol and lipids in the risk of coronary artery disease: the Framingham Heart Study.Can J Cardiol4,SupplA: 5A-10A, 1988."},{"key":"REF11","doi-asserted-by":"crossref","unstructured":"Converse CAand Skinner ER.Lipoprotein Analysis: A Practical Approach. New York: Oxford Univ. Press, 1992.","DOI":"10.1093\/oso\/9780199631926.001.0001"},{"key":"REF12","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112011"},{"key":"REF13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1992.263.1.E79"},{"key":"REF14","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(89)90225-8"},{"key":"REF15","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2002.34704"},{"key":"REF16","doi-asserted-by":"publisher","DOI":"10.1086\/317541"},{"key":"REF17","doi-asserted-by":"crossref","unstructured":"Hadigan C, Miller K, Corcoran C, Anderson E, Basgoz N, and Grinspoon S.Fasting hyperinsulinemia and changes in regional body composition in human immunodeficiency virus-infected women.J Clin Endocrinol Metab84: 1932-1937, 1999.","DOI":"10.1210\/jc.84.6.1932"},{"key":"REF18","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.2.490"},{"key":"REF19","doi-asserted-by":"publisher","DOI":"10.1042\/bj0880137"},{"key":"REF20","doi-asserted-by":"crossref","unstructured":"Hellerstein MK, Grunfeld C, Wu K, Christiansen M, Kaempfer S, Kletke C, and Shackleton CH.Increased de novo hepatic lipogenesis in human immunodeficiency virus infection.J Clin Endocrinol Metab76: 559-565, 1993.","DOI":"10.1210\/jcem.76.3.8445011"},{"key":"REF21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.278.6.E1144"},{"key":"REF22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118645"},{"key":"REF23","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.4.683"},{"key":"REF24","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(91)90152-M"},{"key":"REF25","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114854"},{"key":"REF26","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.16.12.1509"},{"key":"REF27","doi-asserted-by":"publisher","DOI":"10.1097\/00041433-199706000-00004"},{"key":"REF28","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117633"},{"key":"REF29","doi-asserted-by":"publisher","DOI":"10.1038\/nm1201-1327"},{"key":"REF30","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199905070-00009"},{"key":"REF31","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.1.10"},{"key":"REF32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.281.6.E1333"},{"key":"REF33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00411.2002"},{"key":"REF34","doi-asserted-by":"crossref","unstructured":"Patterson BW, Mittendorfer B, Elias N, Satyanarayana R, and Klein S.Use of stable isotopically labeled tracers to measure very low density lipoprotein-triglyceride turnover.J Lipid Res43: 223-233, 2002.","DOI":"10.1016\/S0022-2275(20)30164-4"},{"key":"REF35","doi-asserted-by":"crossref","unstructured":"Patterson BW, Zhao G, Elias N, Hachey DL, and Klein S.Validation of a new procedure to determine plasma fatty acid concentration and isotopic enrichment.J Lipid Res40: 2118-2124, 1999.","DOI":"10.1016\/S0022-2275(20)32435-4"},{"key":"REF36","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.7.700"},{"key":"REF37","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200001070-00006"},{"key":"REF38","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1720155"},{"key":"REF39","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/11.suppl_E.230"},{"key":"REF40","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00777.x"},{"key":"REF41","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(91)90078-B"},{"key":"REF42","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200103010-00004"},{"key":"REF43","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118342"},{"key":"REF44","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00058.2002"},{"key":"REF45","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.276.3.E427"},{"key":"REF46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1959.tb44923.x"},{"key":"REF47","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200211080-00011"},{"key":"REF48","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200111090-00004"},{"key":"REF49","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-020892"},{"key":"REF50","unstructured":"Wolfe RR.Radioactive and Stable Isotope Tracers in Biomedicine: Principles and Practice of Kinetic Analysis. New York: Wiley-Liss, 1992."}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00118.2003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T15:56:49Z","timestamp":1717775809000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpendo.00118.2003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["10.1152\/ajpendo.00118.2003"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00118.2003","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9]]}}}