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Overexpression of FOXF1 in BeWo and HepG2 cells induced the GHV promoter, whereas overexpression of FOXF2 was without effect. Mutagenesis of the FOXF1\/FOXF2 site reduced basal promoter activity by 50\u201360% and markedly attenuated transactivation of the promoter by FOXF1. These studies indicate that FOXF1 induces GHV expression by interaction with a FOXF1\/FOXF2 cis-element in the proximal promoter. <\/jats:p>","DOI":"10.1152\/ajpendo.00128.2006","type":"journal-article","created":{"date-parts":[[2006,6,13]],"date-time":"2006-06-13T23:34:12Z","timestamp":1150241652000},"page":"E947-E951","source":"Crossref","is-referenced-by-count":16,"title":["Transcription factor FOXF1 regulates growth hormone variant gene expression"],"prefix":"10.1152","volume":"291","author":[{"given":"Jefferson P.","family":"Lomenick","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Hubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart","family":"Handwerger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(98)00040-9"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70103-0"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.52.32759"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1990.258.6.E1014"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(02)00081-3"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-71-2-520"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1159\/000181530"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.8.8329"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1993.1139"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2000.13.4.343"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.36.23335"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.8.4482"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2002.0811"},{"key":"R14","unstructured":"McIntyre HD, Serek R, Crane DI, Veveris-Lowe T, Parry A, Johnson S, Leung KC, Ho KK, Bougoussa M, Hennen G, Igout A, Chan FY, Cowley D, Cotterill A, and Barnard R. 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