{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:35:19Z","timestamp":1793853319276,"version":"4.6.1"},"reference-count":85,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 2021-2023 No. 2346"],"award-info":[{"award-number":["PIP 2021-2023 No. 2346"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008992","name":"International Society for Neurochemistry","doi-asserted-by":"publisher","award":["ISN-CAEN Category 1B 2017-2018"],"award-info":[{"award-number":["ISN-CAEN Category 1B 2017-2018"]}],"id":[{"id":"10.13039\/501100008992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"MINCyT | Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2017 No. 1085"],"award-info":[{"award-number":["PICT 2017 No. 1085"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2023,4,1]]},"abstract":"<jats:p>We developed a unique mouse lacking GABAB receptors specifically in Kiss1 cells to evaluate the impact on reproduction and metabolism. Knockout males showed a severe impact on glucose homeostasis, which worsened with aging. These results reinforce the proposed kisspeptin involvement in metabolic regulation and highlight the impact of GABA through GABABR in the regulation of the peripheral pancreas kisspeptin system.<\/jats:p>","DOI":"10.1152\/ajpendo.00129.2022","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T13:16:02Z","timestamp":1674047762000},"page":"E314-E329","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Deletion of GABAB receptors from\n                    <i>Kiss1<\/i>\n                    cells affects glucose homeostasis without altering reproduction in male mice"],"prefix":"10.1152","volume":"324","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4791-8540","authenticated-orcid":false,"given":"Noelia P.","family":"Di Giorgio","sequence":"first","affiliation":[{"name":"Laboratorio de Neuroendocrinolog\u00eda, Instituto de Biolog\u00eda y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Bizzozzero-Hiriart","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroendocrinolog\u00eda, Instituto de Biolog\u00eda y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo N.","family":"Surkin","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroendocrinolog\u00eda, Instituto de Biolog\u00eda y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Repetto","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroendocrinolog\u00eda, Instituto de Biolog\u00eda y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda M.","family":"Bonaventura","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroendocrinolog\u00eda, Instituto de Biolog\u00eda y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florencia N.","family":"Tabares","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroendocrinolog\u00eda, Instituto de Biolog\u00eda y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia S.","family":"Bourguignon","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroendocrinolog\u00eda, Instituto de Biolog\u00eda y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3846-1959","authenticated-orcid":false,"given":"Ayel\u00e9n","family":"Converti","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroendocrinolog\u00eda, Instituto de Biolog\u00eda y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan M. Ria\u00f1o","family":"Gomez","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroendocrinolog\u00eda, Instituto de Biolog\u00eda y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Bettler","sequence":"additional","affiliation":[{"name":"Department of Biomedicine, Pharmazentrum, University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3099-1418","authenticated-orcid":false,"given":"Victoria","family":"Lux-Lantos","sequence":"additional","affiliation":[{"name":"Laboratorio de Neuroendocrinolog\u00eda, Instituto de Biolog\u00eda y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.169.3943.397"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0363-7"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1834399100"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035322"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2014.05.005"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3003-13.2014"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121974"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00211.2013"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1802053115"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0096"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2098-10.2010"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1210\/me.2016-1026"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1621065114"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107974"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1248-y"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00209"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-006-0343-z"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1283-1"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.03.005"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53826-7"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(86)90004-1"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)91203-d"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.11.7139"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1221"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3057-14.2014"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1210\/en.2019-00137"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/jne.12765"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1573"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90491-d"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2167"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.100985"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M700021-JLR200"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200409016"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109298"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.08.024"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.066563"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00615.2006"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05213-5"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.11.007"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1002\/gene.20073"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1300"},{"key":"B42","volume-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos G","year":"2004"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1975"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(86)90081-8"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1159\/000355631"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1159\/000521649"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00547.2019"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/29.9.e45"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00532.2009"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(01)00345-2"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1534"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2015.01.004"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2020.113618"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1159\/000453398"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1765"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0978"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1606"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1530\/REP-13-0368"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-019-0511-x"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3061-14.2014"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.diff.2015.11.001"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1159\/000363609"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2009.01005.x"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0900881"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1159\/000357932"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0078"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1210\/en.2016-1501"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2019.110559"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2008.00866.x"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1172\/JCI34241"},{"key":"B71","unstructured":"The Jackson Laboratory. Breeding Strategies for Maintaining Colonies of Laboratory Mice. Bar Harbor, ME: The Jackson Laboratory, 2009, p. 29. https:\/\/research.uci.edu\/wp-content\/uploads\/JAX-breeding-strategies.pdf [2023 March 1]."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00485.2020"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71075"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2019.06.007"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2011.12.013"},{"key":"B76","first-page":"19","volume":"26","author":"Wilcox G","year":"2005","journal-title":"Clin Biochem Rev"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-001-0750-0"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.279.3.E684"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113020"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2009.01116.x"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-017-0261-z"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2012.07.006"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31073"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00145"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-20563-2"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00129.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T12:43:48Z","timestamp":1679402628000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00129.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,1]]},"references-count":85,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4,1]]}},"alternative-id":["10.1152\/ajpendo.00129.2022"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00129.2022","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,1]]},"assertion":[{"value":"2022-06-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}