{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:20:38Z","timestamp":1793384438384,"version":"4.5.0"},"reference-count":108,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["finance code 001"],"award-info":[{"award-number":["finance code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2022\/08930-6"],"award-info":[{"award-number":["2022\/08930-6"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/13443-1"],"award-info":[{"award-number":["2020\/13443-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/11820-5"],"award-info":[{"award-number":["2019\/11820-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"HHS | NIH | National Institute on Aging","doi-asserted-by":"publisher","award":["AG065993"],"award-info":[{"award-number":["AG065993"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["311939\/2020-1"],"award-info":[{"award-number":["311939\/2020-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["308999\/2022-3"],"award-info":[{"award-number":["308999\/2022-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:p> Whether time-restricted feeding (TRF) combined with resistance exercise training (RT) may be more efficient compared with these interventions alone is still unclear. We show that when combined with RT, TRF provided additional benefits, being more effective in increasing energy expenditure, preventing weight gain, and regulating glycemic homeostasis than each intervention alone. Thus, our results demonstrate that TRF and RT have complementary actions on some synergistic pathways that prevented obesity and hepatic liver accumulation. <\/jats:p>","DOI":"10.1152\/ajpendo.00129.2023","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T14:46:18Z","timestamp":1695825978000},"page":"E513-E528","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Time-restricted feeding combined with resistance exercise prevents obesity and improves lipid metabolism in the liver of mice fed a high-fat diet"],"prefix":"10.1152","volume":"325","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2056-8384","authenticated-orcid":false,"given":"Robson","family":"Damasceno de Lima","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renan","family":"Fudoli Lins Vieira","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor","family":"Rosetto Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7007-197X","authenticated-orcid":false,"given":"Amandine","family":"Chaix","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, Utah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Azevedo Macedo","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Calheiros Antunes","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u00edra","family":"Felonato","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Rosseto Braga","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Castelo Branco Ramos Nakandakari","sequence":"additional","affiliation":[{"name":"Laboratory of Nutritional Genomics (LabGeN), University of Campinas (UNICAMP), Limeira, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2208-3527","authenticated-orcid":false,"given":"Rafael","family":"Calais Gaspar","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9679-8357","authenticated-orcid":false,"given":"Adelino Sanchez","family":"Ramos da Silva","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Rehabilitation and Functional Performance, Ribeir\u00e3o Preto Medical School, and Postgraduate Program in Physical Education and Sport, School of Physical Education and Sport of Ribeir\u00e3o Preto, University of S\u00e3o Paulo (USP), Ribeir\u00e3o Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennys","family":"Esper Cintra","sequence":"additional","affiliation":[{"name":"Laboratory of Nutritional Genomics (LabGeN), University of Campinas (UNICAMP), Limeira, Brazil"},{"name":"Laboratory of Cell Signaling, Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandro","family":"Pereira de Moura","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira, Brazil"},{"name":"Laboratory of Cell Signaling, Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania A.","family":"Mekary","sequence":"additional","affiliation":[{"name":"Massachusetts College of Pharmacy and Health Sciences (MCPHS) University, Boston, Massachusetts, United States"},{"name":"Department of Surgery, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Rochete Ropelle","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira, Brazil"},{"name":"Laboratory of Cell Signaling, Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6129-1521","authenticated-orcid":false,"given":"Jos\u00e9 Rodrigo","family":"Pauli","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology of Exercise (LaBMEx), University of Campinas (UNICAMP), Limeira, Brazil"},{"name":"Laboratory of Cell Signaling, Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2021.104754"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-015-0169-4"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.12474"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2018.06.001"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.032047"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/139239"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2337\/dbi18-0043"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jshs.2019.04.002"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.11.001"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-082018-124320"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-20-0404"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/nu12082185"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1113\/JP280820"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00428.2007"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/nu14224910"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-022-01947-8"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17228307"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.08.023"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3741-2"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150447"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X13484078"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1042\/CS20150308"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1641-z"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2016.3202"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2011.242073"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i15.4382"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/srep31106"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26393"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20949"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12581"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.14854"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.26780"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-18-0567"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2020.113149"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.12.001"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030571"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2016.02.005"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000623"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.11.029"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1139\/h04-002"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2016.01.011"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-68-2-374"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.06.019"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1258\/002367707779399518"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s11062-016-9577-7"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1590\/S1517-86922011000100010"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82352-8"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55618-5"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20701"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.935805"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217738730"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.04.019"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-208868"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.31744\/einstein_journal\/2020AO4784"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1055\/a-0885-9872"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2023.112116"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.11.004"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.10.1729"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2008.38"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.08.004"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23607"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e318058a603"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2018.10.009"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00097.2005"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2010.054189"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2016.08.002"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.08.018"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.205583"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-015-0063-9"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195912"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.02.032"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10563-9"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2017.12.004"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.04.010"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109543"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14868"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00332"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3390\/nu11071500"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqaa192"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22756"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114513001359"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-2057"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.04.059"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.3233\/NHA-170036"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22518"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.858320"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.02.016"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1113\/JP279455"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126402"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30882"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2022.5191"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101051"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.24272\/j.issn.2095-8137.2020.051"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.04.004"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120413"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-73344-9_18"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00355.2015"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2014.07.011"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2014.03.012"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2016-0280"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00510.2010"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000223"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-011-2098-6"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.48"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00038.2012"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0227"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.702025"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00129.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T15:07:46Z","timestamp":1700060866000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00129.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,1]]},"references-count":108,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,11,1]]}},"alternative-id":["10.1152\/ajpendo.00129.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00129.2023","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,1]]},"assertion":[{"value":"2023-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-13","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}