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When HrH4 expression was knocked down in the subcutaneous white adipose tissue (scWAT), browning and lipolysis effects triggered by cold were ablated, and the oxygen consumption was also lowered both at the normal and cold conditions. Moreover, mice exhibited browned scWAT, accelerated metabolic rates, and tolerance to hypothermia when 4-methylhistamine (4MH), a selective HrH4 agonist, was adjacently injected to the scWAT. Consistent with these findings, 4MH also triggered the browning and lipolytic effects in cultured C3H10T1\/2 adipocytes. Mechanically, we demonstrated that p38\/MAPK and ERK\/MAPK pathways were involved in these processes. In conclusion, our findings have uncovered an effective role of HrH4 in adipose tissue browning. <\/jats:p>","DOI":"10.1152\/ajpendo.00131.2019","type":"journal-article","created":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T19:43:15Z","timestamp":1569354195000},"page":"E1158-E1171","source":"Crossref","is-referenced-by-count":14,"title":["Stimulation of histamine H4 receptor participates in cold-induced browning of subcutaneous white adipose tissue"],"prefix":"10.1152","volume":"317","author":[{"given":"Ya-xin","family":"Zhao","sequence":"first","affiliation":[{"name":"Institute of Stem Cell Research and Regenerative Medicine of Institutes of Biomedical Sciences, Fudan University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-bao","family":"Pan","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Department of Biochemistry and Molecular Biology of School of 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