{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:37:35Z","timestamp":1785487055970,"version":"3.56.0"},"reference-count":37,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2002,2,1]]},"abstract":"<jats:p>The aim of this study was to determine the effect of high levels of free fatty acids (FFA) and\/or hyperglycemia on hepatic glycogenolysis and gluconeogenesis. Intralipid was infused peripherally in 18-h-fasted conscious dogs maintained on a pancreatic clamp in the presence (FFA\u2009+\u2009HG) or absence (FFA\u2009+\u2009EuG) of hyperglycemia. In the control studies, Intralipid was not infused, and euglycemia (EuG) or hyperglycemia (HG) was maintained. Insulin and glucagon were clamped at basal levels in all four groups. The arterial blood glucose level increased by 50% in the HG and FFA\u2009+\u2009HG groups. It did not change in the EuG and FFA\u2009+\u2009EuG groups. Arterial plasma FFA increased by \u223c140% in the FFA\u2009+\u2009EuG and FFA\u2009+\u2009HG groups but did not change significantly either in the EuG or HG groups. Arterial glycerol levels increased by \u223c150% in both groups. Overall (3-h) net hepatic glycogenolysis was 196 \u00b1 26 mg\/kg in the EuG group. It decreased by 96 \u00b1 20, 82 \u00b1 16, and 177 \u00b1 22 mg\/kg in the HG, FFA\u2009+\u2009EuG, and FFA\u2009+\u2009HG groups, respectively. Overall (3-h) hepatic gluconeogenic flux was 128 \u00b1 22 mg\/kg in the EuG group, but it was suppressed by 30 \u00b1 9 mg\/kg in response to hyperglycemia. It was increased by 59 \u00b1 12 and 56 \u00b1 10 mg\/kg in the FFA\u2009+\u2009EuG and FFA\u2009+\u2009HG groups, respectively. In conclusion, an increase in plasma FFA and glycerol significantly inhibited hepatic glycogenolysis and markedly stimulated hepatic gluconeogenesis.<\/jats:p>","DOI":"10.1152\/ajpendo.00136.2001","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T20:08:24Z","timestamp":1425067704000},"page":"E402-E411","source":"Crossref","is-referenced-by-count":56,"title":["Effects of free fatty acids on hepatic glycogenolysis and gluconeogenesis in conscious dogs"],"prefix":"10.1152","volume":"282","author":[{"given":"Chang An","family":"Chu","sequence":"first","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Sherck","sequence":"additional","affiliation":[{"name":"Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 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