{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:48:40Z","timestamp":1790048920376,"version":"4.0.1"},"reference-count":78,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/100000071","name":"HHS | NIH | National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD085573"],"award-info":[{"award-number":["HD085573"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"HHS | NIH | National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD072891"],"award-info":[{"award-number":["HD072891"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"USDA | National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["2013-67015-20438"],"award-info":[{"award-number":["2013-67015-20438"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["CRIS 6250-51000-055"],"award-info":[{"award-number":["CRIS 6250-51000-055"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:p>\n                    Postnatal growth of lean mass is commonly blunted in preterm infants and may contribute to short- and long-term morbidities. To determine whether preterm birth alters the protein anabolic response to feeding, piglets were delivered at term or preterm, and fractional protein synthesis rates (K\n                    <jats:sub>s<\/jats:sub>\n                    ) were measured at 3 days of age while fasted or after an enteral meal. Activation of signaling pathways that regulate protein synthesis and degradation were determined. Relative body weight gain was lower in preterm than in term. Gestational age at birth (GAB) did not alter fasting plasma glucose or insulin, but when fed, plasma insulin and glucose rose more slowly, and reached peak value later, in preterm than in term. Feeding increased K\n                    <jats:sub>s<\/jats:sub>\n                    in longissimus dorsi (LD) and gastrocnemius muscles, heart, pancreas, and kidney in both GAB groups, but the response was blunted in preterm. In diaphragm, lung, jejunum, and brain, feeding increased K\n                    <jats:sub>s<\/jats:sub>\n                    regardless of GAB. Liver K\n                    <jats:sub>s<\/jats:sub>\n                    was greater in preterm than term and increased with feeding regardless of GAB. In all tissues, changes in 4EBP1, S6K1, and PKB phosphorylation paralleled changes in K\n                    <jats:sub>s<\/jats:sub>\n                    . In LD, eIF4E\u00b7eIF4G complex formation, phosphorylation of TSC2, mTOR, and rpS6, and association of mammalian target of rapamycin (mTOR1) complex with RagA, RagC, and Rheb were increased by feeding and blunted by prematurity. There were no differences among groups in LD protein degradation markers. Our results demonstrate that preterm birth reduces weight gain and the protein synthetic response to feeding in muscle, pancreas, and kidney, and this is associated with blunted insulin- and\/or amino acid-induced translation initiation signaling.\n                  <\/jats:p>","DOI":"10.1152\/ajpendo.00151.2019","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T15:53:41Z","timestamp":1568130821000},"page":"E839-E851","source":"Crossref","is-referenced-by-count":21,"title":["Prematurity blunts the feeding-induced stimulation of translation initiation signaling and protein synthesis in muscle of neonatal piglets"],"prefix":"10.1152","volume":"317","author":[{"given":"Jane K.","family":"Naberhuis","sequence":"first","affiliation":[{"name":"United States Department of Agriculture, Agricultural Research Service, Children\u2019s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agus","family":"Suryawan","sequence":"additional","affiliation":[{"name":"United States Department of Agriculture, Agricultural Research Service, Children\u2019s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanh V.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"United States Department of Agriculture, Agricultural Research Service, Children\u2019s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Hernandez-Garcia","sequence":"additional","affiliation":[{"name":"United States Department of Agriculture, Agricultural Research Service, Children\u2019s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Cruz","sequence":"additional","affiliation":[{"name":"Division of Pediatric Surgery, Michael E. 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