{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T21:07:43Z","timestamp":1772140063080,"version":"3.50.1"},"reference-count":28,"publisher":"American Physiological Society","issue":"6","content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:p> Inhibition of LMPTP with a small-molecular inhibitor, Cmpd23, improves glucose tolerance in mice as reported earlier. However, genetic deficiency of the LMPTP gene, Acp, has limited effects on glucose metabolism but leads to mild cardiac hypertrophy in mice. The findings suggest the potential off-target effects of Cmpd23 and call for reevaluation of LMPTP as a therapeutic target for the treatment of insulin resistance and type 2 diabetes. <\/jats:p>","DOI":"10.1152\/ajpendo.00161.2021","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T11:48:16Z","timestamp":1649677696000},"page":"E517-E527","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Loss of low-molecular-weight protein tyrosine phosphatase shows limited improvement in glucose tolerance but causes mild cardiac hypertrophy in mice"],"prefix":"10.1152","volume":"322","author":[{"given":"Sharon","family":"Jensen-Cody","sequence":"first","affiliation":[{"name":"Merck & Co., Inc., South San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin S.","family":"Coyne","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc., South San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xunshan","family":"Ding","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc., South San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anu","family":"Sebin","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc., South San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jen","family":"Vogel","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc., South San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaclyn","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc., South San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas W.","family":"Rosahl","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc., West Point, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather H.","family":"Zhou","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc., Kenilworth, New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugues","family":"Jacobs","sequence":"additional","affiliation":[{"name":"CELPHEDIA, PHENOMIN, Institut Clinique de la Souris, Universit\u00e9 de Strasbourg, CNRS, INSERM, Illkirch, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-France","family":"Champy","sequence":"additional","affiliation":[{"name":"CELPHEDIA, PHENOMIN, Institut Clinique de la Souris, Universit\u00e9 de Strasbourg, CNRS, INSERM, Illkirch, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghina Bou","family":"About","sequence":"additional","affiliation":[{"name":"CELPHEDIA, PHENOMIN, Institut Clinique de la Souris, Universit\u00e9 de Strasbourg, CNRS, INSERM, Illkirch, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saswata","family":"Talukdar","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc., South San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjiang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc., South San Francisco, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05482"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009191"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407766-9.00017-1"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5407.1544"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2174\/1568026619666190201152153"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-2132"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(02)00697-8"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1124\/mol.119.116319"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1021\/bi011389l"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200567200"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2016.07.001"},{"key":"B12","first-page":"95","volume":"50","author":"Bottini N","year":"2002","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"B13","volume-title":"Probe Reports from the NIH Molecular Libraries Program","author":"Ardecky RJ","year":"2010"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30307"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/path.4594"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7355"},{"key":"B17","first-page":"509","volume":"69","author":"Lucarini N","year":"1997","journal-title":"Hum Biol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S1096-7192(02)00120-8"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2344"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609626200"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb15907.x"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.D023788"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(95)90127-2"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2011.00699.x"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.01.044"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1021\/jm200607g"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.05.027"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.46"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00161.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T16:20:31Z","timestamp":1654100431000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00161.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,1]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6,1]]}},"alternative-id":["10.1152\/ajpendo.00161.2021"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00161.2021","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,1]]},"assertion":[{"value":"2021-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-05","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}