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Mild glucose intolerance develops in RIP-FRK male mice of at least 4 mo of age. This effect is accompanied by reduced glucose-stimulated insulin secretion in vivo and reduced second-phase insulin secretion in response to glucose and arginine upon pancreas perfusion. Islets isolated from the FRK transgenic mice display a glucose-induced insulin secretory response in vitro similar to that of control islets. However, islet blood flow per islet volume is decreased in the FRK transgenic mice. These mice also exhibit a reduced islet capillary lumen diameter as shown by electron microscopy. Total body weight and pancreas weight are not significantly affected, but the \u03b2-cell mass is increased. The data suggest that long-term expression of active FRK in \u03b2-cells causes an in vivo insulin-secretory defect, which may be the consequence of islet vascular abnormalities that yield a decreased islet blood flow. <\/jats:p>","DOI":"10.1152\/ajpendo.00168.2006","type":"journal-article","created":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T03:23:21Z","timestamp":1166585001000},"page":"E1183-E1190","source":"Crossref","is-referenced-by-count":16,"title":["Glucose intolerance and reduced islet blood flow in transgenic mice expressing the FRK tyrosine kinase under the control of the rat insulin promoter"],"prefix":"10.1152","volume":"292","author":[{"given":"Cecilia","family":"Anner\u00e9n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Welsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Jansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1720145"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03402213"},{"key":"R3","unstructured":"Atef N, Ktorza A, Penicaud L. 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