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Adipose tissue secretes many adipokines that are central to the regulation of metabolism. In this study, we investigated whether transplantation of normal adipose tissue could ameliorate severe hepatic steatosis, IR, and dyslipidemia in lipoatrophic seipin knockout (SKO) mice. Normal adipose tissue from wild-type mice was transplanted into 6-wk-old SKO mice. At 4 mo after adipose tissue transplantation (AT), the transplanted fat survived with detectable blood vessels, and the reduced levels of plasma leptin, a major adipokine, were dramatically increased. Severe hepatic steatosis, IR, and dyslipidemia in SKO mice were ameliorated after AT. In addition, abnormal hepatic lipogenesis and \u03b2-oxidation gene expression in SKO mice were improved after AT. Our results suggest that AT may be an effective treatment to improve lipodystrophy-associated metabolic disorders.<\/jats:p>","DOI":"10.1152\/ajpendo.00180.2018","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T19:59:58Z","timestamp":1542743998000},"page":"E54-E62","source":"Crossref","is-referenced-by-count":27,"title":["Adipose tissue transplantation ameliorates lipodystrophy-associated metabolic disorders in seipin-deficient mice"],"prefix":"10.1152","volume":"316","author":[{"given":"Huan","family":"Wang","sequence":"first","affiliation":[{"name":"Experimental and Translational Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China"},{"name":"Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, School of Basic Medical Sciences, Ministry of Education, Peking University Health Science Center, Beijing, 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