{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T10:01:31Z","timestamp":1781517691805,"version":"3.54.1"},"reference-count":43,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2013,8,15]]},"abstract":"<jats:p> Quantifying the effect size of acute exercise on insulin sensitivity (SI<jats:sub>exercise<\/jats:sub>) and simultaneous measurement of glucose disappearance (R<jats:sub>d<\/jats:sub>), endogenous glucose production (EGP), and meal glucose appearance in the postprandial state has not been developed in humans. To do so, we studied 12 healthy subjects [5 men, age 37.1 \u00b1 3.1 yr, body mass index 24.1 \u00b1 1.1 kg\/m<jats:sup>2<\/jats:sup>, fat-free mass (FFM) 50.9 \u00b1 3.9 kg] during moderate exercise at 50% V\u0307o<jats:sub>2max<\/jats:sub> for 75 min, 120\u2013195 min after a triple-tracer mixed meal consumed at time 0. Tracer infusion rates were adjusted to achieve constant tracer-to-tracee ratio and minimize non-steady-state errors. Glucose turnover was estimated by accounting for the nonstationary kinetics introduced by exercise. Insulin sensitivity index was calculated in each subject both in the absence [time ( t) = 0\u2013120 min, SI<jats:sub>rest<\/jats:sub>] and presence ( t = 0\u2013360 min, SI<jats:sub>exercise<\/jats:sub>) of physical activity. EGP at t = 0 min (13.4 \u00b1 1.1 \u03bcM\u00b7kg FFM<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>) fell at t = 120 min (2.4 \u00b1 0.4 \u03bcM\u00b7kg FFM<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>) and then rapidly rose almost eightfold at t = 180 min (18.2 \u00b1 2.6 \u03bcM\u00b7kg FFM<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>) before gradually falling at t = 360 min (10.6 \u00b1 0.9 \u03bcM\u00b7kg FFM<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>). R<jats:sub>d<\/jats:sub> rapidly peaked at t = 120 min at the start of exercise (89.5 \u00b1 11.6 \u03bcM\u00b7kg FFM<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>) and then gradually declined at t = 195 min (26.4 \u00b1 3.3 \u03bcM\u00b7kg FFM<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>) before returning to baseline at t = 360 min. SI<jats:sub>exercise<\/jats:sub> was significantly higher than SI<jats:sub>rest<\/jats:sub> (21.6 \u00b1 3.7 vs. 12.5 \u00b1 2.0 10<jats:sup>\u22124<\/jats:sup> dl\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup> per \u03bcU\/ml, P &lt; 0.0005). Glucose turnover was estimated for the first time during exercise with the triple-tracer technique. Our results, applying state-of-the-art techniques, show that moderate exercise almost doubles postprandial insulin sensitivity index in healthy subjects. <\/jats:p>","DOI":"10.1152\/ajpendo.00182.2013","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T00:42:35Z","timestamp":1372812155000},"page":"E557-E566","source":"Crossref","is-referenced-by-count":38,"title":["Postprandial glucose fluxes and insulin sensitivity during exercise: A study in healthy individuals"],"prefix":"10.1152","volume":"305","author":[{"given":"Michele","family":"Schiavon","sequence":"first","affiliation":[{"name":"Department of Information Engineering, University of Padova, Padova, Italy; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Hinshaw","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Division of Endocrinology and Metabolism, Mayo College of Medicine, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashwini","family":"Mallad","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Division of Endocrinology and Metabolism, Mayo College of Medicine, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara Dalla","family":"Man","sequence":"additional","affiliation":[{"name":"Department of Information Engineering, University of Padova, Padova, Italy; 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