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Offspring were weaned, and analyses were performed on the mature offspring that did not have access to running wheels during any portion of their lives. Perinatal exercise caused improved glucose disposal following an oral glucose challenge in both female and male adult offspring ( P &lt; 0.05 for both). Blood glucose concentrations were reduced to lower values in response to an intraperitoneal insulin tolerance test for both female and male adult offspring of parents with access to running wheels ( P &lt; 0.05 and P &lt; 0.01, respectively). Male offspring from exercised dams showed increased percent lean mass and decreased fat mass percent compared with male offspring from sedentary dams ( P &lt; 0.01 for both), but these parameters were unchanged in female offspring. These data suggest that short-term maternal voluntary exercise prior to and during healthy pregnancy and nursing can enhance long-term glucose homeostasis in offspring.<\/jats:p>","DOI":"10.1152\/ajpendo.00213.2012","type":"journal-article","created":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T01:36:09Z","timestamp":1346204169000},"page":"E1061-E1068","source":"Crossref","is-referenced-by-count":100,"title":["Perinatal exercise improves glucose homeostasis in adult offspring"],"prefix":"10.1152","volume":"303","author":[{"given":"Lindsay G.","family":"Carter","sequence":"first","affiliation":[{"name":"Graduate Center for Nutritional Sciences, College of Medicine, University of Kentucky, Lexington, Kentucky;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn N.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Gerontology, National Institute on Aging, National Institutes of Health, Baltimore, 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