{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:30:23Z","timestamp":1789633823250,"version":"build-2803163510"},"reference-count":79,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["#2013\/07607-8"],"award-info":[{"award-number":["#2013\/07607-8"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["#2018\/26080-4"],"award-info":[{"award-number":["#2018\/26080-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["#2019\/00728-0"],"award-info":[{"award-number":["#2019\/00728-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:p> Vertical sleeve gastrectomy (VSG) decreases insulin secretion, endoplasmic reticulum (ER) stress, and inflammation in pancreatic islets from obese mice. In addition, VSG increased fibroblast growth factor (FGF)15 circulating levels in obese mice, as well as the expression of FGF receptor 1 ( Fgfr1) and its coreceptor \u03b2-klotho ( Klb), both in pancreatic islets from VSG mice and in INS-1E \u03b2-cells treated with the serum from these mice. Serum from operated mice protects INS-1E cells from dysfunction and apoptosis, which was mediated by FGF15\/19. <\/jats:p>","DOI":"10.1152\/ajpendo.00218.2023","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T15:35:50Z","timestamp":1703086550000},"page":"E134-E147","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Vertical sleeve gastrectomy improves glucose-insulin homeostasis by enhancing \u03b2-cell function and survival via FGF15\/19"],"prefix":"10.1152","volume":"326","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0891-0055","authenticated-orcid":false,"given":"Gabriela M.","family":"Soares","sequence":"first","affiliation":[{"name":"Obesity and Comorbidities Research Center (OCRC), Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra L.","family":"Balbo","sequence":"additional","affiliation":[{"name":"Obesity and Comorbidities Research Center (OCRC), Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil"},{"name":"Laboratory of Endocrine Physiology and Metabolism, Biological Sciences and Health Center, Western Paran\u00e1 State University (UNIOESTE), Cascavel, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela A.","family":"Bronczek","sequence":"additional","affiliation":[{"name":"Obesity and Comorbidities Research Center (OCRC), Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6411-2947","authenticated-orcid":false,"given":"Jean F.","family":"Vettorazzi","sequence":"additional","affiliation":[{"name":"Latin-American Institute of Life and Nature Sciences, Federal University of Latin-American Integration (UNILA), Foz do Iguacu, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Marmentini","sequence":"additional","affiliation":[{"name":"Obesity and Comorbidities Research Center (OCRC), Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Zangerolamo","sequence":"additional","affiliation":[{"name":"Obesity and Comorbidities Research Center (OCRC), Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4806-7218","authenticated-orcid":false,"given":"L\u00edcio A.","family":"Velloso","sequence":"additional","affiliation":[{"name":"Obesity and Comorbidities Research Center (OCRC), Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3212-369X","authenticated-orcid":false,"given":"Everardo M.","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Obesity and Comorbidities Research Center (OCRC), Department of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.706978"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19451"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3945\/an.113.005488"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nature05482"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00075-6"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.170"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2015.06.013"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-009-9954-z"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00469.2013"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.10.009"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-009-0068-4"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-011-1755-5"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-012-1855-0"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21658"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20548"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-310572"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0816"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00726.2005"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171965"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-02838-2"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2017.04.005"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1435"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2021-002287"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1751"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1498"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3390\/nu11030585"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/nature13135"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309871"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24914-y"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-018-3216-x"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2022.111617"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1002\/wdev.176"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.09.001"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.03.019"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1126\/science.1198363"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1671"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1210\/endo.143.5.8850"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101113"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2013.10.002"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021729"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.6.1487"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1995.268.2.E336"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202100841R"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23169427"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28689"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-19-0201"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-016-0160-4"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.2337\/db18-1305"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009427107"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1530\/JME-15-0306"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.05.001"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101330"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-015-4236-4"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-012-1263-5"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102481"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-13974-0"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128294"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00561"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1938"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0252607"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1424"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101021"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.126688"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.01.027"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00134"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017868"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00175.2020"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.2337\/db21-0574"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13038"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.10.041"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2020.113498"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.79"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20121393"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312975"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030505"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.601349"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.06.025"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116046"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-019-0475-1"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00218.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T15:30:30Z","timestamp":1707406230000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00218.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":79,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2,1]]}},"alternative-id":["10.1152\/ajpendo.00218.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00218.2023","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,1]]},"assertion":[{"value":"2023-07-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}