{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:54:52Z","timestamp":1790913292283,"version":"4.1.0"},"reference-count":44,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2003,1,1]]},"abstract":"<jats:p> Isoforms of the thyroid hormone receptor ( TR) \u03b1 and TR\u03b2 genes mediate thyroid hormone action. How TR isoforms modulate tissue-specific thyroid hormone (TH) action remains largely unknown. The steroid receptor coactivator-1 (SRC-1) is among a group of transcriptional coactivator proteins that bind to TRs, along with other members of the nuclear receptor superfamily, and modulate the activity of genes regulated by TH. Mice deficient in SRC-1 possess decreased tissue responsiveness to TH and many steroid hormones; however, it is not known whether or not SRC-1-mediated activation of TH-regulated gene transcription in peripheral tissues, such as heart and liver, is TR isoform specific. We have generated mice deficient in TR\u03b1 and SRC-1, as well as in TR\u03b2 and SRC-1, and investigated thyroid function tests and effects of TH deprivation and TH treatment compared with wild-type (WT) mice or those deficient in either TR or SRC-1 alone. The data show that 1) in the absence of TR\u03b1 or TR\u03b2, SRC-1 is important for normal growth; 2) SRC-1 modulates TR\u03b1 and TR\u03b2 effects on heart rate; 3) two new TR\u03b2-dependent markers of TH action in the liver have been identified, osteopontin (upregulated) and glutathione S-transferase (downregulated); and 4) SRC-1 may mediate the hypersensitivity to TH seen in liver of TR\u03b1-deficient mice. <\/jats:p>","DOI":"10.1152\/ajpendo.00226.2002","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T15:23:27Z","timestamp":1425050607000},"page":"E36-E46","source":"Crossref","is-referenced-by-count":35,"title":["Specificity of thyroid hormone receptor subtype and  steroid receptor coactivator-1 on thyroid hormone action"],"prefix":"10.1152","volume":"284","author":[{"given":"Peter M.","family":"Sadow","sequence":"first","affiliation":[{"name":"Departments of Medicine and"},{"name":"Pathology, University of Chicago, Chicago, Illinois 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