{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:08:21Z","timestamp":1792271301042,"version":"4.4.0"},"reference-count":28,"publisher":"American Physiological Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2014,10,15]]},"abstract":"<jats:p>The hepatoportal area is an important glucohomeostatic metabolic sensor, sensing hypoglycemia, hyperglycemia, and hormones such as glucagon-like peptide-1 (GLP-1). We have reported previously that activation of hepatoportal sensors by intraportal infusion of glucose and GLP-1 or by subcutaneous administration of GLP-1 receptor activator exenatide and of intraportal glucose improved glycemia independent of corresponding changes in pancreatic hormones. It is not clear whether this effect is mediated via the portal vein (PV) or by direct action on the liver itself. To test whether receptors in the PV mediate exenatide's beneficial effect on glucose tolerance, we performed 1) paired oral glucose tolerance tests (OGTT) with and without exenatide and 2) intravenous glucose tolerance tests before and after PV denervation in canines. Denervation of the portal vein affected oral glucose tolerance; post-denervation (POST-DEN) OGTT glucose and insulin AUC were 50% higher than before denervation ( P = 0.01). However, portal denervation did not impair exenatide's effect to improve oral glucose tolerance (exenatide effect: 48 \u00b1 12 mmol\u00b7l<jats:sup>\u22121<\/jats:sup>\u00b7min before vs. 64 \u00b1 26 mmol\u00b7l<jats:sup>\u22121<\/jats:sup>\u00b7min after, P = 0.67). There were no changes in insulin sensitivity or secretion during IVGTTs. Portal vein sensing might play a role in controlling oral glucose tolerance during physiological conditions but not in pharmacological activation of GLP-1 receptors by exenatide.<\/jats:p>","DOI":"10.1152\/ajpendo.00244.2014","type":"journal-article","created":{"date-parts":[[2014,8,13]],"date-time":"2014-08-13T14:00:15Z","timestamp":1407938415000},"page":"E644-E652","source":"Crossref","is-referenced-by-count":13,"title":["Hepatic portal vein denervation impairs oral glucose tolerance but not exenatide\u2019s effect on glycemia"],"prefix":"10.1152","volume":"307","author":[{"given":"Viorica","family":"Ionut","sequence":"first","affiliation":[{"name":"Diabetes and Obesity Research Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Valeria B.","family":"Castro","sequence":"additional","affiliation":[{"name":"Diabetes and Obesity Research Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orison O.","family":"Woolcott","sequence":"additional","affiliation":[{"name":"Diabetes and Obesity Research Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darko","family":"Stefanovski","sequence":"additional","affiliation":[{"name":"Diabetes and Obesity Research Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malini S.","family":"Iyer","sequence":"additional","affiliation":[{"name":"Diabetes and Obesity Research Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josiane L.","family":"Broussard","sequence":"additional","affiliation":[{"name":"Diabetes and Obesity Research Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Burch","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram","family":"Elazary","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cedars Sinai Medical Center, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathryn M.","family":"Kolka","sequence":"additional","affiliation":[{"name":"Diabetes and Obesity Research Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasmik","family":"Mkrtchyan","sequence":"additional","affiliation":[{"name":"Diabetes and Obesity Research Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac Asare","family":"Bediako","sequence":"additional","affiliation":[{"name":"Diabetes and Obesity Research Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard N.","family":"Bergman","sequence":"additional","affiliation":[{"name":"Diabetes and Obesity Research Institute and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.2007.S212"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1089\/152091503322641060"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1797"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050117"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2337\/diab.40.1.155"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23569"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.11.7143"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.2.399"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.1.8"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1794"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-1709-3"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00106.2005"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90222.2008"},{"key":"B14","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/cphy.c120018","volume":"3","author":"Jensen KJ","year":"2013","journal-title":"Compr Physiol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00275.2007"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1185\/030079908X253870"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.2337\/db05-1665"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2009.05.012"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1997.273.5.E981"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(96)00071-9"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/121.8.1255"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111601"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(03)00146-1"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s005350050177"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0153"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.3.373"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2010.01.006"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0875"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00244.2014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T10:36:39Z","timestamp":1649932599000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpendo.00244.2014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,15]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,10,15]]}},"alternative-id":["10.1152\/ajpendo.00244.2014"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00244.2014","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,15]]}}}