{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:34:03Z","timestamp":1791686043611,"version":"4.3.4"},"reference-count":113,"publisher":"American Physiological Society","issue":"2","funder":[{"DOI":"10.13039\/100017618","name":"HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases","doi-asserted-by":"publisher","award":["DK131328"],"award-info":[{"award-number":["DK131328"]}],"id":[{"id":"10.13039\/100017618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","award":["34851"],"award-info":[{"award-number":["34851"]}],"id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2024,2,1]]},"abstract":"<jats:p> A new extended model of oral glucose tolerance test (OGTT) has been developed that includes glucagon dynamics and incretin contribution to insulin secretion. The model allows the estimation of parameters related to \u03b1- and \u03b2-cell dysfunction, insulin sensitivity, and incretin action. A new function describing the influx of glucose from the gut has been introduced. A new rubric for estimating the incretin effect directly from the OGTT experiment has been developed. The effect of glucose dose was also investigated. <\/jats:p>","DOI":"10.1152\/ajpendo.00278.2023","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T15:48:01Z","timestamp":1702482481000},"page":"E182-E205","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["An extended minimal model of OGTT: estimation of \u03b1- and \u03b2-cell dysfunction, insulin resistance, and the incretin effect"],"prefix":"10.1152","volume":"326","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8292-1759","authenticated-orcid":false,"given":"Vijaya","family":"Subramanian","sequence":"first","affiliation":[{"name":"Institute for Computational Medicine, Johns Hopkins University, Baltimore, Maryland, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonatan I.","family":"Bagger","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"},{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinayak","family":"Harihar","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, United States"},{"name":"Biophysics Graduate Group, University of California, Berkeley, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens J.","family":"Holst","sequence":"additional","affiliation":[{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filip K.","family":"Knop","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"},{"name":"Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"},{"name":"Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Villsb\u00f8ll","sequence":"additional","affiliation":[{"name":"Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark"},{"name":"Clinical Research, Steno Diabetes Center Copenhagen, Herlev, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/s0950-351x(05)80207-1"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2016.6"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0351"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab065"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.09.010"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13129"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(15)00482-9"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00349"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(97)90006-8"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3109\/03009734.2016.1156789"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-023-00817-4"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2015.39.1.1"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.010.Diabetes"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0355-7"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00512.2019"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1210\/er.2006-0026"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2435"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-014-0555-4"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S319895"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2013.00037"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.suppl_3.S16"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14496"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(75)92375-2"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106297"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3264-2"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.coemr.2022.100379"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.575789"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/psp.2013.30"},{"key":"B29","first-page":"300","author":"Vandekerckhove J","year":"2015","journal-title":"The Oxford Handbook of Computational and Mathematical Psychology"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/0169-2607(86)90106-9"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1979.236.6.e667"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1198"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2007.893506"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00451.2010"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1109\/10.995680"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222833"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1186\/s12976-019-0115-3"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.611147"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.583016"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/0025-5564(82)90050-5"},{"key":"B41","first-page":"31","volume":"1","author":"Sulston KW","year":"2006","journal-title":"Atlantic Electron J Math"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00705.2009"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2015.0146"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3219-7"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073154"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4682-9-16"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070875"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10051060"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.911616"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbs.2013.05.006"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.602"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2006.883792"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00319.2003"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1177\/1932296813514502"},{"key":"B55","volume-title":"The Skew-Normal and Related Families","author":"Azzaleni A","year":"2014"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.11.6982"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01450.x"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1995.268.1.e21"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.6.3979"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.1.e2"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(90)90186-G"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01663.x"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190627"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00665.2010"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01452.x"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90444.2008"},{"key":"B67","volume-title":"Mathematica. Version 12.0","author":"Wolfram Reasearch, Inc.","year":"2019"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1109\/TAC.1974.1100705"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.3758\/bf03206482"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1186\/s12918-015-0180-0"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110398"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00139.2011"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.1994.tb00273.x"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2021-002447"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1093\/jee\/39.2.269"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1214\/aoms\/1177730491"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.2007.s5"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3003-0"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1999.277.2.e283"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400639"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0354"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2017.12.003"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.2337\/db16-0240"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab019"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.8.1807"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.9.2213"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.069195"},{"key":"B88","first-page":"19","volume":"26","author":"Wilcox G","year":"2005","journal-title":"Clin Biochem Rev"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13005"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90579-9"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1007\/BF02427280"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.2007.s117"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2017.05.003"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00251.2015"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00139.2003"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1172\/JCI105685"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-s227"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2019.170183"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12792"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.2165\/11585880-000000000-00000"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1080\/00401706.1969.10490657"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1002\/9780470749296"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2016.04.022"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2018.10.016"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01454.x.Physiologic"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.28"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.02.037"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00069.2016"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.2337\/db14-1052"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021873"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.3390\/nu11081878"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118411"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1021\/acs.iecr.1c00552"}],"updated-by":[{"DOI":"10.1152\/ajpendo.00278.2023_cor","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2024,4,15]],"date-time":"2024-04-15T00:00:00Z","timestamp":1713139200000}}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00278.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T16:21:46Z","timestamp":1712593306000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00278.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,1]]},"references-count":113,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2,1]]}},"alternative-id":["10.1152\/ajpendo.00278.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00278.2023","relation":{"correction":[{"id-type":"doi","id":"10.1152\/ajpendo.00278.2023_COR","asserted-by":"object"}]},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,1]]},"assertion":[{"value":"2023-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-27","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}