{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:46:12Z","timestamp":1770486372304,"version":"3.49.0"},"reference-count":50,"publisher":"American Physiological Society","issue":"6","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["R00 HL 122507"],"award-info":[{"award-number":["R00 HL 122507"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["U24 DK 059637"],"award-info":[{"award-number":["U24 DK 059637"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2018,12,1]]},"abstract":"<jats:p> Angiotensin-converting enzyme (ACE) inhibitors reduce body weight, lower blood pressure (BP), and improve insulin sensitivity in animal models of cardiometabolic syndrome. These effects are generally attributed to reduced angiotensin (ANG) II formation; however, these therapies also increase levels of ANG-(1\u20137), a beneficial hormone opposing ANG II actions. We hypothesized that this ANG-(1\u20137) generation contributes to the insulin-sensitizing effects of ACE inhibition in obese mice. Adult male C57BL\/6J mice were placed on a 60% high-fat diet for 11 wk. During the last 3 wk of diet, mice received normal water or water containing the ACE inhibitor captopril (50 mg\/l) as well as the ANG-(1\u20137) mas receptor antagonist A779 (400 or 800 ng\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>) or saline vehicle via subcutaneous osmotic minipumps. At the end of treatment, arterial BP was measured, and hyperinsulinemic-euglycemic clamps were performed in conscious obese mice receiving vehicle, captopril, captopril plus A779, or A779 ( n = 6\u201313\/group). Captopril reduced body weight (28\u2009\u00b1\u20092 vs. 41\u2009\u00b1\u20092 g saline; P = 0.001), lowered systolic BP (109\u2009\u00b1\u20096 vs. 144\u2009\u00b1\u20097 mmHg saline; P = 0.041), and improved whole-body insulin sensitivity (steady-state glucose infusion rate: 31\u2009\u00b1\u20094 vs. 16\u2009\u00b1\u20092 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup> saline; P = 0.001) in obese mice. A779 attenuated captopril-mediated improvements in insulin sensitivity (23\u2009\u00b1\u20092 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7min<jats:sup>\u22121<\/jats:sup>; P = 0.042), with no effect on body weight (32\u2009\u00b1\u20092 g; P = 0.441) or BP (111\u2009\u00b1\u20097 mmHg; P = 0.788). There was no effect of A779 alone on cardiometabolic outcomes. These data suggest that insulin-sensitizing effects of ACE inhibition are in part due to activation of ANG-(1\u20137)\/ mas receptor pathways and provide new insight into mechanisms underlying the positive metabolic effects of these therapies. <\/jats:p>","DOI":"10.1152\/ajpendo.00281.2018","type":"journal-article","created":{"date-parts":[[2018,10,9]],"date-time":"2018-10-09T16:49:47Z","timestamp":1539103787000},"page":"E1204-E1211","source":"Crossref","is-referenced-by-count":28,"title":["Angiotensin-(1\u20137) contributes to insulin-sensitizing effects of angiotensin-converting enzyme inhibition in obese mice"],"prefix":"10.1152","volume":"315","author":[{"given":"Justin","family":"Loloi","sequence":"first","affiliation":[{"name":"Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda 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