{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T03:49:20Z","timestamp":1772164160469,"version":"3.50.1"},"reference-count":50,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>Type 2 diabetes is characterized by hyperglycemia, a deficit in \u03b2-cells, increased \u03b2-cell apoptosis, and islet amyloid derived from islet amyloid polypeptide (IAPP). These characteristics are recapitulated in the human IAPP transgenic (HIP) rat. We developed a mathematical model to quantify \u03b2-cell turnover and applied it to nondiabetic wild type (WT) vs. HIP rats from age 2 days to 10 mo to establish 1) whether \u03b2-cell formation is derived exclusively from \u03b2-cell replication, or whether other sources of \u03b2-cells (OSB) are present, and 2) to what extent, if any, there is attempted \u03b2-cell regeneration in the HIP rat and if this is through \u03b2-cell replication or OSB. We conclude that formation and maintenance of adult \u03b2-cells depends largely (\u223c80%) on formation of \u03b2-cells independent from \u03b2-cell duplication. Moreover, this source adaptively increases in the HIP rat, implying attempted \u03b2-cell regeneration that substantially slows loss of \u03b2-cell mass.<\/jats:p>","DOI":"10.1152\/ajpendo.00284.2009","type":"journal-article","created":{"date-parts":[[2009,5,26]],"date-time":"2009-05-26T22:18:20Z","timestamp":1243376300000},"page":"E323-E330","source":"Crossref","is-referenced-by-count":24,"title":["Dynamics of \u03b2-cell turnover: evidence for \u03b2-cell turnover and regeneration from sources of \u03b2-cells other than \u03b2-cell replication in the HIP rat"],"prefix":"10.1152","volume":"297","author":[{"given":"Erica","family":"Manesso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianna 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