{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:51:16Z","timestamp":1793839876801,"version":"4.6.1"},"reference-count":32,"publisher":"American Physiological Society","issue":"3","funder":[{"name":"NIH","award":["P01AG055369"],"award-info":[{"award-number":["P01AG055369"]}]},{"name":"NIH","award":["R01CA231219"],"award-info":[{"award-number":["R01CA231219"]}]},{"name":"NIH","award":["R01HL158691"],"award-info":[{"award-number":["R01HL158691"]}]},{"name":"NIH","award":["R01AG069698"],"award-info":[{"award-number":["R01AG069698"]}]},{"name":"NIH","award":["RF1AG061834"],"award-info":[{"award-number":["RF1AG061834"]}]},{"name":"NIH","award":["R01AG068405"],"award-info":[{"award-number":["R01AG068405"]}]},{"name":"NIH","award":["P30AG068345"],"award-info":[{"award-number":["P30AG068345"]}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:p>MOTS-c, a mitochondrial microprotein, attenuates immobilization-induced skeletal muscle atrophy. MOTS-c treatment improves systemic inflammation and skeletal muscle AKT\/FOXOs signaling pathways. Furthermore, unbiased RNA sequencing and subsequent assays revealed that MOTS-c prevents lipid infiltration in skeletal muscle. Since lipid accumulation is one of the common pathologies among other skeletal muscle atrophies induced by aging, obesity, cancer cachexia, and denervation, MOTS-c treatment could be effective in other muscle atrophy models as well.<\/jats:p>","DOI":"10.1152\/ajpendo.00285.2023","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T10:15:31Z","timestamp":1704276931000},"page":"E207-E214","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Mitochondrial-derived microprotein MOTS-c attenuates immobilization-induced skeletal muscle atrophy by suppressing lipid infiltration"],"prefix":"10.1152","volume":"326","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0520-6214","authenticated-orcid":false,"given":"Hiroshi","family":"Kumagai","sequence":"first","affiliation":[{"name":"The Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, United States"},{"name":"Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4435-5757","authenticated-orcid":false,"given":"Su-Jeong","family":"Kim","sequence":"additional","affiliation":[{"name":"The Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendan","family":"Miller","sequence":"additional","affiliation":[{"name":"The Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiharu","family":"Natsume","sequence":"additional","affiliation":[{"name":"Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan"},{"name":"Faculty of Medicine, Tokai University, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxiang","family":"Wan","sequence":"additional","affiliation":[{"name":"The Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michi Emma","family":"Kumagai","sequence":"additional","affiliation":[{"name":"The Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, United States"},{"name":"Department of Psychiatry, David Geffen School of Medicine, University of California, Los Angeles, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"Ricardo","family":"Ramirez","sequence":"additional","affiliation":[{"name":"The Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin Hyung","family":"Lee","sequence":"additional","affiliation":[{"name":"The Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Sato","sequence":"additional","affiliation":[{"name":"The Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemal H.","family":"Mehta","sequence":"additional","affiliation":[{"name":"The Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4595-971X","authenticated-orcid":false,"given":"Kelvin","family":"Yen","sequence":"additional","affiliation":[{"name":"The Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0035-8366","authenticated-orcid":false,"given":"Pinchas","family":"Cohen","sequence":"additional","affiliation":[{"name":"The Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61031-9"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62000-6"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-022-00440-0"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.2001.00853.x"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1661"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1113\/JP275444"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.02.009"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102944"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-019-01758-0"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-020-00262-5"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00249.2020"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.112056"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1172\/JCI158449"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.106174"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202529"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/genes14020286"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.14171"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20790-0"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15377"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00275.2020"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2021.130048"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00462.2020"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90558.2008"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/647348"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1039\/c8fo01992d"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.8306"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118145"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.06.008"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175835"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050048"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/nm956"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00446.2009"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00285.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T10:47:07Z","timestamp":1707994027000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00285.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3,1]]}},"alternative-id":["10.1152\/ajpendo.00285.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00285.2023","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,1]]},"assertion":[{"value":"2023-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}