{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:27:08Z","timestamp":1775305628502,"version":"3.50.1"},"reference-count":43,"publisher":"American Physiological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2002,4,1]]},"abstract":"<jats:p> The effects of leptin on cocaine- and amphetamine-regulated transcript (CART) and agouti-related protein (AGRP) expression in the hypothalamic arcuate nucleus of obese A<jats:sup>y<\/jats:sup>\/a mice were investigated. CART mRNA expression was upregulated by 41% and AGRP mRNA downregulated by 78% in hyperleptinemic A<jats:sup>y<\/jats:sup>\/a mice relative to levels in lean a\/a mice. The mRNA expression of these neuropeptides in either young nonobese A<jats:sup>y<\/jats:sup>\/a mice or rats treated with SHU-9119, a synthetic melanocortin-4 receptor (MC4R) antagonist, did not differ significantly from that in the corresponding controls. After a 72-h fast, which decreased the concentration of serum leptin, CART and AGRP mRNA expression decreased and increased, respectively, in A<jats:sup>y<\/jats:sup>\/a mice. The expression levels of these neuropeptides in leptin-deficient A<jats:sup>y<\/jats:sup>\/a ob\/ob double mutants were comparable to those in a\/a ob\/ob mice. Leptin thus modulates both CART and AGRP mRNA expression in obese A<jats:sup>y<\/jats:sup>\/amice, whereas leptin signals are blocked at the MCR4R level. Taken together, the present findings indicate that differential expression of these neuropeptides in A<jats:sup>y<\/jats:sup>\/a and ob\/obmice results in dissimilar progression toward obesity. <\/jats:p>","DOI":"10.1152\/ajpendo.00292.2001","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T20:09:00Z","timestamp":1425067740000},"page":"E967-E973","source":"Crossref","is-referenced-by-count":17,"title":["Hyperleptinemia in <i>A<sup>y<\/sup>\/a<\/i> mice upregulates arcuate  cocaine- and amphetamine-regulated transcript expression"],"prefix":"10.1152","volume":"282","author":[{"given":"Yoshio","family":"Tsuruta","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I, School of Medicine, Oita Medical University, Oita 879-5593, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Yoshimatsu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I, School of Medicine, 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