{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T03:15:59Z","timestamp":1777086959603,"version":"3.51.4"},"reference-count":30,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K11012"],"award-info":[{"award-number":["18K11012"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2020,11,1]]},"abstract":"<jats:p> Prolonged, uninterrupted sitting is demonstrated to acutely impair glucose homeostasis, but it also leads to detrimental cardiovascular health effects. We examined whether ischemic preconditioning (IPC) prevents the impact of prolonged sitting-induced glucose intolerance and measured related influencing factors such as (para)sympathetic nerve activity [assessed by heart rate variability (HRV)] and blood pressure during 2 h of prolonged sitting. In this randomized, controlled crossover study, 15 healthy participants (80% men) with a mean age of 21\u2009\u00b1\u20091 yr (means\u2009\u00b1\u2009SD) and body mass index of 25.0\u2009\u00b1\u20092.4 kg\/m<jats:sup>2<\/jats:sup> performed IPC (IPC, 4\u2009\u00d7\u20095-min 220-mmHg unilateral occlusion at the thigh muscle) or a sham intervention (sham, 4\u2009\u00d7\u20095 min 20-mmHg), followed by 2 h of sitting. After IPC or sham intervention, fingertip blood glucose was measured before and after 30, 60, 90, and 120 min of 75 g of glucose ingestions. Blood glucose responses during an oral glucose tolerance test were significantly attenuated, resulting in a lower area under the curve when sitting was preceded by a bout of IPC than sham ( P &lt; 0.05). IPC increased high-frequency oscillations and decreased the ratio of low-frequency-to-high-frequency oscillations at 120 min in HRV ( P &lt; 0.05). Moreover, a lower blood pressure was observed with IPC compared with sham ( P &lt; 0.05). Prolonged sitting or IPC did not affect cerebrovascular responses ( P &gt; 0.05). Collectively, these results indicate that the application of IPC before prolonged, uninterrupted sitting bout was associated with a better glucose tolerance and prevented impairment in (para)sympathetic nerve activity and blood pressure in healthy young men and women. <\/jats:p>","DOI":"10.1152\/ajpendo.00302.2020","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T09:56:52Z","timestamp":1598867812000},"page":"E821-E826","source":"Crossref","is-referenced-by-count":9,"title":["Ischemic preconditioning prevents impact of prolonged sitting on glucose tolerance and markers of cardiovascular health but not cerebrovascular responses"],"prefix":"10.1152","volume":"319","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5784-5694","authenticated-orcid":false,"given":"Masahiro","family":"Horiuchi","sequence":"first","affiliation":[{"name":"Division of Human Environmental Science, Mount Fuji Research Institute, Kamiyoshida, Fujiyoshida, Yamanashi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick H. J.","family":"Thijssen","sequence":"additional","affiliation":[{"name":"Research Institute of Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, United Kingdom"},{"name":"Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.7326\/M14-1651"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/nu10121947"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-019-04297-1"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00310.2018"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001101"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107911"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1931"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00635.2003"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s12576-011-0172-9"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvn114"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00123.2005"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.5.1990"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00384.2016"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1589\/jpts.27.3711"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20910053"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15081710"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069910"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.04.044"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13046"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1113\/EP086441"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14412-1"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.05.011"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1113\/EP085566"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.2.375"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000000479"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2016.06.021"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00823.2016"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019217"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12373"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2006.11.079"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00302.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T15:03:37Z","timestamp":1603292617000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00302.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,1]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,11,1]]}},"alternative-id":["10.1152\/ajpendo.00302.2020"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00302.2020","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,1]]}}}