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Key novel findings are the increased prevalence of FOXP3\n                    <jats:sup>+<\/jats:sup>\n                    lymphocytes without a corresponding increase in CD25\n                    <jats:sup>+<\/jats:sup>\n                    cells, suggesting a population of chronically activated regulatory T cells. It also identifies a distinct PD-L1 expression pattern in follicular cells (both membrane and cytoplasm), suggesting a protective feedback mechanism against autoimmune attack.\n                  <\/jats:p>","DOI":"10.1152\/ajpendo.00306.2025","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:56Z","timestamp":1764028856000},"page":"E38-E46","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Interplay between expression of PD-L1 on thyrocytes and intrathyroidal lymphocytes and FOXP3 as a marker of regulatory T lymphocytes in Hashimoto thyroiditis"],"prefix":"10.1152","volume":"330","author":[{"given":"Ana Carolina","family":"Barros Silva","sequence":"first","affiliation":[{"name":"University of Campinas","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid Iara","family":"Damas","sequence":"additional","affiliation":[{"name":"University of Campinas","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Aparecida","family":"Moma","sequence":"additional","affiliation":[{"name":"University of Campinas","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Icleia Siqueira","family":"Barreto","sequence":"additional","affiliation":[{"name":"University of Campinas","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7434-5701","authenticated-orcid":false,"given":"Denise Engelbrecht","family":"Zantut-Wittmann","sequence":"additional","affiliation":[{"name":"University of Campinas","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5368473"},{"volume-title":"StatPearls","year":"2025","author":"Kaur J","key":"B2"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/979167"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.0231"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.06.015"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.05.009"},{"key":"B7","volume-title":"Regulatory T Cells and Autoimmune Diseases","author":"Dwivedi MK","year":"2024","edition":"1"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.083543"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-019-9579-2"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02374"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.959477"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2010.00923.x"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1002\/art.27417"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.5825"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-2337"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1159\/000331857"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2012.751981"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.07.009"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1111\/apm.13218"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.05.013"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00306.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T18:56:35Z","timestamp":1766084195000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00306.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,1]]}},"alternative-id":["10.1152\/ajpendo.00306.2025"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00306.2025","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"type":"print","value":"0193-1849"},{"type":"electronic","value":"1522-1555"}],"subject":[],"published":{"date-parts":[[2026,1,1]]},"assertion":[{"value":"2025-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}