{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:02:05Z","timestamp":1772578925583,"version":"3.50.1"},"reference-count":41,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:p> Although testosterone (T) has striking effects on mature skeletal size and structure, it is not clear whether this depends exclusively on adult circulating levels of T or whether additional early-life factors also play a role. We have compared the androgen-deficient hypogonadal ( hpg) mutant mouse with intact, orchidectomized, and T-treated non- hpg mice to determine relative contributions of adult and perinatal T to bone growth and development. At 3 wk of age, although trabecular and cortical bone structure was normal, bone turnover was significantly altered in hpg male mice; osteoid volume (OV\/BV) and osteoblast surface (ObS\/BS) were significantly lower and osteoclast surface (OcS\/BS) significantly higher in hpg mice compared with age-matched non- hpg mice, pointing to a role for the perinatal T surge in determining bone turnover levels before sexual maturity. At 9 wk of age, the hpg bone phenotype mimicked closely that of age-matched non- hpg mice that had been orchidectomized at 3 wk of age, including low trabecular bone mass and high bone turnover. These bone phenotypes of hpg and orchidectomized non- hpg mice were all prevented by replacement doses of T or dihydrotestosterone (DHT), suggesting that these are determined by adult sex steroid hormones. In contrast, a short bone phenotype that could not be prevented by T or DHT treatment was observed in 9-wk-old hpg mice yet not in intact or castrated non- hpg mice. These data suggest a role for the perinatal T surge in determining adult bone length and confirms that adult circulating T determines adult bone density. <\/jats:p>","DOI":"10.1152\/ajpendo.00311.2005","type":"journal-article","created":{"date-parts":[[2005,10,5]],"date-time":"2005-10-05T03:18:08Z","timestamp":1128482288000},"page":"E456-E462","source":"Crossref","is-referenced-by-count":64,"title":["Perinatal testosterone surge is required for normal adult bone size but not for normal bone remodeling"],"prefix":"10.1152","volume":"290","author":[{"given":"Natalie A.","family":"Sims","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny","family":"Spaliviero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Handelsman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus J.","family":"Seibel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199707103370204"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1038\/269338a0"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1210\/endo-113-2-535"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1390057"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1007\/BF03343854"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20056"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-106-3-"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.2.3758"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.9.6958"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1210\/me.2002-0032"},{"key":"R11","unstructured":"Horn D, Rivas P, McCluskey B, Mundy GR, and Gutierrez G. 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