{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T00:12:20Z","timestamp":1794269540956,"version":"4.9.0"},"reference-count":30,"publisher":"American Physiological Society","issue":"1","funder":[{"name":"Killam Accelerator Research Fellowship","award":["NA"],"award-info":[{"award-number":["NA"]}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-169116"],"award-info":[{"award-number":["PJT-169116"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJ9-166217"],"award-info":[{"award-number":["PJ9-166217"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000245","name":"Michael Smith Foundation for Health Research","doi-asserted-by":"publisher","award":["16890"],"award-info":[{"award-number":["16890"]}],"id":[{"id":"10.13039\/501100000245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2024,1,1]]},"abstract":"<jats:p> Exogenous ketone supplements can acutely lower blood glucose, suggesting therapeutic potential in individuals with impaired glucose metabolism. However, the effect of exogenous ketones on glucose metabolism in adults with type 2 diabetes has not been investigated in a controlled setting. In adults with type 2 diabetes, ketone monoester ingestion did not lower blood glucose acutely in a fasted state and did not improve glycemic control across thrice daily premeal ingestion across 14 days. <\/jats:p>","DOI":"10.1152\/ajpendo.00332.2023","type":"journal-article","created":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T15:16:04Z","timestamp":1700666164000},"page":"E61-E72","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["The effect of acute and 14-day exogenous ketone supplementation on glycemic control in adults with type 2 diabetes: two randomized controlled trials"],"prefix":"10.1152","volume":"326","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3240-964X","authenticated-orcid":false,"given":"Kaja","family":"Falkenhain","sequence":"first","affiliation":[{"name":"Faculty of Health and Social Development, School of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara F.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Faculty of Health and Social Development, School of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7145-0522","authenticated-orcid":false,"given":"Hashim","family":"Islam","sequence":"additional","affiliation":[{"name":"Faculty of Health and Social Development, School of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8051-1542","authenticated-orcid":false,"given":"Helena","family":"Neudorf","sequence":"additional","affiliation":[{"name":"Faculty of Health and Social Development, School of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoning H.","family":"Cen","sequence":"additional","affiliation":[{"name":"Department of Cellular & Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7523-9433","authenticated-orcid":false,"given":"James D.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Cellular & Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Madden","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Singer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1782-7074","authenticated-orcid":false,"given":"Jeremy J.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Kinesiology, Faculty of Science, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9796-2008","authenticated-orcid":false,"given":"Jonathan P.","family":"Little","sequence":"additional","affiliation":[{"name":"Faculty of Health and Social Development, School of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071816-064916"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00848"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.c500213200"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3804"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12230"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmac036"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqz232"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa925"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxaa417"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13423"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.264"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2012.04.008"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)60842-7"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230x-11-122"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3768\/rtipress.2009.mr.0009.0903"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/cpbi.86"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw313"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1096822"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1111\/dme.14385"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac595"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.2337\/diab.25.9.776"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1992.262.3.e353"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.9.1836"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.300"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.2337\/diab.40.10.1319"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3710-9"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2016.03.004"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa483"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2020-0644"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00332.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T18:37:00Z","timestamp":1703183820000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00332.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,1]]}},"alternative-id":["10.1152\/ajpendo.00332.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00332.2023","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,1]]},"assertion":[{"value":"2023-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}