{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T19:20:56Z","timestamp":1782760856068,"version":"3.54.5"},"reference-count":27,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/100000066","name":"HHS | NIH | National Institute of Environmental Health Sciences (NIEHS)","doi-asserted-by":"publisher","award":["R01ES024516"],"award-info":[{"award-number":["R01ES024516"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"publisher","award":["81500216"],"award-info":[{"award-number":["81500216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China (NSFC)","doi-asserted-by":"publisher","award":["81770805"],"award-info":[{"award-number":["81770805"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2018,7,1]]},"abstract":"<jats:p> Environmental stressors that encounter in early-life and cause abnormal fetal and\/or neonatal development may increase susceptibility to non-communicable diseases such as diabetes. Maternal exposure to ambient fine particulate matter (PM<jats:sub>2.5<\/jats:sub>) is associated with various fetal abnormalities, suggesting that it may program offspring\u2019s susceptibility to diabetes. In the present study, we therefore examined whether maternal exposure to diesel exhaust PM<jats:sub>2.5<\/jats:sub> (DEP), one of the major sources of ambient PM<jats:sub>2.5<\/jats:sub> in urban areas, programs adult offspring\u2019s glucose metabolism. Female C57Bl\/6J mice were intratracheally instilled with DEP or vehicle throughout a 7-wk preconceptional period, gestation, and lactation, and the glucose homeostasis of their adult male offspring was assessed. Intraperitoneal glucose tolerance test (IPGTT) revealed that the maternal exposure to DEP significantly impaired adult male offspring\u2019s glucose tolerance. Unexpectedly, it did not influence their insulin sensitivity, whereas it significantly decreased their glucose-induced insulin secretion (GIIS). This deficit in insulin secretion was corroborated by their significant decrease in arginine-induced insulin secretion. Histological analysis demonstrated that the deficit in insulin secretion was accompanied by the decrease in pancreatic islet and \u03b2 cell sizes. To differentiate the effects of maternal exposure to DEP before birth and during lactation, some offspring were cross-fostered once born. We did not observe any significant effect of cross-fostering on the glucose homeostasis of adult male offspring and the function and morphology of their \u03b2 cells. Prenatal exposure to DEP programs the morphology and function of \u03b2 cells and thus homeostatic regulation of glucose metabolism in adult male offspring. <\/jats:p>","DOI":"10.1152\/ajpendo.00336.2017","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T17:52:39Z","timestamp":1514310759000},"page":"E72-E80","source":"Crossref","is-referenced-by-count":33,"title":["Prenatal exposure to diesel exhaust PM<sub>2.5<\/sub> causes offspring \u03b2 cell dysfunction in adulthood"],"prefix":"10.1152","volume":"315","author":[{"given":"Minjie","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, Maryland"},{"name":"Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, Maryland"},{"name":"Department of Bile Pancreatic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, Maryland"},{"name":"Department of Electrocardiography, the People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, Maryland"},{"name":"Department of Pharmacology, Medical College of Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianglin","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, Maryland"},{"name":"Department of Occupational and Environmental Health, School of Public Health, Nantong University, Nantong, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sufang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, Maryland"},{"name":"Department of Geriatric Endocrinology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziying","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, Maryland"},{"name":"Department of Endocrinology, the People's Hospital of Zhengzhou University (Henan Provincial People's Hospital), Zhengzhou, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhekang","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2017.03.107"},{"key":"B2","volume-title":"Estimation of Human Toxicity from Animal Inhalation Toxicity Data. 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