{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:00:32Z","timestamp":1792659632832,"version":"4.5.0"},"reference-count":25,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2002,3,1]]},"abstract":"<jats:p> The interrelationship between insulin and leptin resistance in young Fischer 344 (F344) rats was studied. Young F344 and Sprague-Dawley (SD) rats were fed regular chow. F344 animals had two- to threefold higher insulin and triglyceride concentrations and increased stores of triglycerides within liver and muscle. F344 animals gained more body fat. Both acyl-CoA oxidase (ACO) and carnitine palmitoyltransferase I gene expression were 20\u201350% less in F344 animals than in age-matched SD animals. Peroxisome proliferator-activated receptor-\u03b1 gene expression was reduced in 70-day-old F344 animals. Finally, resistin gene expression was similar in 70-day-old SD and F344 animals. Resistin gene expression increased fivefold in F344 animals and twofold in SD animals from 70 to 130 days, without a change in insulin sensitivity. We conclude that young F344 animals have both insulin and leptin resistance, which may lead to diminished fatty oxidation and accumulation of triglycerides in insulin-sensitive target tissues. We did not detect a role for resistin in the etiology of insulin resistance in F344 animals. <\/jats:p>","DOI":"10.1152\/ajpendo.00346.2001","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T20:08:54Z","timestamp":1425067734000},"page":"E626-E633","source":"Crossref","is-referenced-by-count":49,"title":["Lipid metabolism and resistin gene expression  in insulin-resistant Fischer 344 rats"],"prefix":"10.1152","volume":"282","author":[{"given":"James R.","family":"Levy","sequence":"first","affiliation":[{"name":"Section of Endocrinology and Metabolism, McGuire Veterans Administration Medical Center and"},{"name":"Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23249"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byrd","family":"Davenport","sequence":"additional","affiliation":[{"name":"Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23249"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Clore","sequence":"additional","affiliation":[{"name":"Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23249"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne","family":"Stevens","sequence":"additional","affiliation":[{"name":"Section of Endocrinology and Metabolism, McGuire Veterans Administration Medical Center and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119865"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602013340503"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1210\/endo-118-3-1139"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.22.16638"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.5.933"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.5.677"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6223"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2000.279.6.R2057"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100028200"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-12932"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1460509"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.23.10878"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008553200"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.278.5.E892"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.279.5.E1088"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00271-5"},{"key":"B17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1530\/eje.0.1360173","volume":"136","author":"Nyholm B","year":"1997","journal-title":"Eur J Endocrinol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.5.749"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/69.4.584"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.9.4637"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/35053000"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90151-5"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.5.2327"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100189200"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.15.8898"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00346.2001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T18:47:16Z","timestamp":1567968436000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/ajpendo.00346.2001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3,1]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3,1]]}},"alternative-id":["10.1152\/ajpendo.00346.2001"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00346.2001","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3,1]]}}}