{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:49:04Z","timestamp":1783478944568,"version":"3.55.0"},"reference-count":37,"publisher":"American Physiological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2013,3,1]]},"abstract":"<jats:p> This study compares the functional consequences of levothyroxine (T<jats:sub>4<\/jats:sub>) treatment during pregnancy as well as the acute affects of triiodothyronine (T<jats:sub>3<\/jats:sub>) on spontaneous uterine contractile activities observed in vitro. Uterine biopsies were obtained from consenting women undergoing elective caesarean at term ( n = 28). Spontaneous contractile activities from T<jats:sub>4<\/jats:sub>-treated pregnant women ( n = 8) were compared with control patients ( n = 20) by isometric tension measurements. Effects of acute T<jats:sub>3<\/jats:sub> and T<jats:sub>4<\/jats:sub> on control tissues were also monitored. Area under the curve, amplitude, time to peak, duration, and frequency were quantified. In uterine strips from women treated for hypothyroidism, phasic uterine contractions of larger amplitude (+77%) were observed, with a prolonged duration at 90% relaxation (+138%) and reduced frequency (\u221255%) compared with values of the control group. The addition of exogenous T<jats:sub>3<\/jats:sub> in vitro on control strips induced a significant increase in the duration of the contractions and a significant decrease in frequency ( P &lt; 0.05), which partially mimics the results obtained in strips from T<jats:sub>4<\/jats:sub>-treated women. Significant modifications of contractile properties were observed in strips from pregnant women treated with levothyroxine, consistent with those observed with the addition of exogenous T<jats:sub>3<\/jats:sub>. Clinical practices of modern obstetrics should take into account the effect of thyroid hormones on uterine contractions' time course to ensure a tighter followup at the end of pregnancy to achieve safer delivery. <\/jats:p>","DOI":"10.1152\/ajpendo.00346.2012","type":"journal-article","created":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T04:56:39Z","timestamp":1355892999000},"page":"E478-E485","source":"Crossref","is-referenced-by-count":6,"title":["Chronic levothyroxine and acute T<sub>3<\/sub> treatments enhance the amplitude and time course of uterine contractions in human"],"prefix":"10.1152","volume":"304","author":[{"given":"St\u00e9phanie","family":"Corriveau","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada;"},{"name":"Departmenr of Physiology and Biophysics, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Charles","family":"Pasquier","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Blouin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Bellabarba","sequence":"additional","affiliation":[{"name":"Service of Endocrinology, Faculty of Medicine and health sciences, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Departmenr of Physiology and Biophysics, Universit\u00e9 de Sherbrooke, Sherbrooke, Quebec, Canada; 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