{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T06:12:30Z","timestamp":1793340750840,"version":"4.5.0"},"reference-count":338,"publisher":"American Physiological Society","issue":"5","funder":[{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT-2018-159590"],"award-info":[{"award-number":["PJT-2018-159590"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2017-06272"],"award-info":[{"award-number":["RGPIN-2017-06272"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2022,5,1]]},"abstract":"<jats:p> Persistent organic pollutants (POPs) are a diverse family of contaminants that show widespread global dispersion and bioaccumulation. Humans are continuously exposed to POPs through diet, air particles, and household and commercial products; POPs are consistently detected in human tissues, including the pancreas. Epidemiological studies show a modest but consistent correlation between exposure to POPs and increased diabetes risk. The goal of this review is to provide an overview of epidemiological evidence and an in-depth evaluation of the in vivo and in vitro evidence that POPs cause \u03b2-cell toxicity. We review evidence for six classes of POPs: dioxins, polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), organophosphate pesticides (OPPs), flame retardants, and per- and polyfluoroalkyl substances (PFAS). The available data provide convincing evidence implicating POPs as a contributing factor driving impaired glucose homeostasis, \u03b2-cell dysfunction, and altered metabolic and oxidative stress pathways in islets. These findings emphasize the need to consider the endocrine pancreas in toxicity assessments. Our review also highlights significant gaps in the literature assessing islet-specific endpoints after both in vivo and in vitro POP exposure. In addition, most rodent studies do not consider the impact of biological sex or secondary metabolic stressors in mediating the effects of POPs on glucose homeostasis and \u03b2-cell function. We discuss key gaps and limitations that should be assessed in future studies. <\/jats:p>","DOI":"10.1152\/ajpendo.00358.2021","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T13:00:52Z","timestamp":1644843652000},"page":"E383-E413","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":77,"title":["Persistent organic pollutants and \u03b2-cell toxicity: a comprehensive review"],"prefix":"10.1152","volume":"322","author":[{"given":"Myriam P.","family":"Hoyeck","sequence":"first","affiliation":[{"name":"Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geronimo","family":"Matteo","sequence":"additional","affiliation":[{"name":"Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada"},{"name":"Department of Biology, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Environmental Health Science and Research Bureau, Health Canada, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"MacFarlane","sequence":"additional","affiliation":[{"name":"Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ineli","family":"Perera","sequence":"additional","affiliation":[{"name":"Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2326-7819","authenticated-orcid":true,"given":"Jennifer E.","family":"Bruin","sequence":"additional","affiliation":[{"name":"Department of Biology and Institute of Biochemistry, Carleton University, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.19"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00317-7"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00101"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3437"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2897"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf5094"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15010078"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.10001"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1177\/2042018819897046"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1104597"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1205502"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1210\/er.2013-1084"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2016.11.013"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-2449"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0543"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-008-1066-0"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2013.01.006"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2329"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.eti.2018.08.002"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-016-0051"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.marpolbul.2004.05.015"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2006.05.107"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2661"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-05035-0"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1995.1025"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2014.07.015"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab050"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57973-0"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060030"},{"key":"B31","first-page":"7","volume":"22","author":"Poitout V","year":"1996","journal-title":"Diabetes Metab"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.44.3.306"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.241182"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1080\/19382014.2015.1024405"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3390\/jcm7030054"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.482"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.604998"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07201-1"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.teac.2017.12.001"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8884"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jea.7500370"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1080\/15287398909531288"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2013.10.039"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopen.2018.05.001"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-018-0019-2"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cotox.2017.10.003"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12282"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3109\/10408444.2010.524635"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020757"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1039\/c3em00086a"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm371"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a117575"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16193566"},{"key":"B54","first-page":"259","volume":"103","author":"Consonni D","year":"2012","journal-title":"Med Lav"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1080\/10915810290096540"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/jes.2008.63"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2012.05.008"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001730"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.2307\/3433813"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1136\/oem.56.4.270"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1186\/s12995-016-0095-8"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.2486\/indhealth.41.149"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20385"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200001000-00010"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199705000-00005"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145818"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181c2fc6e"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2005.11.004"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0800012"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1136\/oem.55.2.126"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2006.11.002"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1080\/1354750032000158420"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2008.06.002"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu307"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0072"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-2116"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-2190"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-007-0755-4"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199705000-00005"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.5.5663"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/56.2.431"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(85)90314-X"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(87)90031-X"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1177\/019262338801600301"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2004.09.014"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1459"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101104"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.4255\/mcpharmacol.09.15"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b02830"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2004.12.004"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.129103"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1177\/1091581809336885"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2007.01.017"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.04.025"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2013.06.026"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.067827"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063289"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808180106"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1136\/oem.58.11.747"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2011.11.013"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1080\/19382014.2019.1566684"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12616"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00672"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12465"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01632.x"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.48.4.706"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.3389\/ftox.2021.685840"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1515\/REVEH.2006.21.1.1"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.6b01723"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-013-1926-0"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1080\/07853890310008224"},{"key":"B112","volume-title":"Safety Evaluation of Certain Food Additives and Contaminants, Supplement 1: Non-Dioxin-Like Polychlorinated Biphenyls","author":"World Health Organization","year":"2016"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S264851"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.2174\/187569209788654005"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1021\/tx050196m"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003996"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.3109\/10408449409049308"},{"key":"B118","volume-title":"Stockholm Convention on Persistent Organic Pollutants","author":"UN-Environmental Program","year":"2004"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1177\/0748233715587849"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1021\/es800778q"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2010.10.099"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2012.12.001"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2017.12.010"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2017.02.002"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph6123179"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-010-1683-2"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1104247"},{"key":"B128","first-page":"3498","volume":"66","author":"Radikova Z","year":"2004","journal-title":"Organohalogen Compd"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2016.06.001"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1342"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1021\/es300712g"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2016.01.087"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1509902"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10315"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2020.109345"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.5456"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.07.075"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901480"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15030539"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2015.03.037"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000220553.84350.c5"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-2303"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1177\/0960327107076886"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2016.09.002"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2013.09.066"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2014.11.007"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015977"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.2337\/db17-0188"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2014.11.001"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e318212fab9"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2014.07.039"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.08.009"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1205421"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801380"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1002848"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1080\/10937404.2016.1246391"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.01.009"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.06.019"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.02.026"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b01597"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.03.101"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1080\/15287394.2013.796503"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(96)00557-7"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1999.8728"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1042\/bj2100345"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1042\/bj2120439"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2019.109875"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1515\/intox-2016-0012"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-017-2050-2"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1210\/js.2017-00480"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1289\/EHP353"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.5487\/TR.2016.32.1.021"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.10.047"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1021\/es203303r"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1243"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1186\/s12199-018-0692-5"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwn028"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1007\/BF01057414"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007503"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2015.07.002"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-4-28"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2010.02.012"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0800281"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2014.11.002"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52200-x"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10258"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2016.12.069"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(80)90160-5"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2014.02.004"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2014.12.017"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/545802"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2020.104767"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2015.06.046"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54579-z"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1308"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-015-2479-y"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-005617"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001693"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0229430"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(93)90066-M"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfx266"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1186\/s12940-019-0488-0"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2016.02.003"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-005-0051-z"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1104323"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.10.033"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmr121"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1210\/edrv.22.5.0440"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2371"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.07.108"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1832"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2006.08.007"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1007\/s001280146"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1177\/0960327106075064"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(79)90327-2"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(02)00128-5"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.11.072"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2008.06.006"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(82)90692-X"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1080\/15376520500191623"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.3109\/01480545.2013.838780"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2004.03.009"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2004.07.002"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2007.02.001"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006930511459"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2013.04.003"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2012.11.008"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1139\/y88-188"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(90)90125-5"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2010.07.003"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12158"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2008.09.002"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2016.04.009"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2012.01.009"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.2478\/10004-1254-60-2009-1917"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2007.05.001"},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01655.x"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.06.010"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.2337\/db13-1371"},{"key":"B242","unstructured":"Daly I. 2003. A 24-month oral toxicity\/oncogenicity study of malathion in the rat via dietary administration. Final report: Lab Project No. 90-3641.1996. Unpublished study prepared by Huntington Life Sciences. EPA MRID 43942901: Toxicological Profile for Malathion."},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph6020478"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.6559"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.1021\/es9004834"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2017.07.009"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.00108147"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.1002\/ieam.5630010404"},{"key":"B249","first-page":"3820","volume":"66","author":"Geyer HJ","year":"2004","journal-title":"Organohalogen Compd"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8350"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106041"},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2014.03.073"},{"key":"B253","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2008.04.005"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.03.025"},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2017.12.065"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1003089"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1021\/acs.estlett.9b00582"},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2012.03.067"},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.1021\/es401144c"},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.1021\/es901672m"},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2014.11.058"},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2014.01.010"},{"key":"B263","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2012.09.028"},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.105321"},{"key":"B265","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2019.105034"},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.1021\/es5025299"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2018.06.045"},{"key":"B268","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2016.01.035"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.11.006"},{"key":"B270","doi-asserted-by":"publisher","DOI":"10.1139\/a11-010"},{"key":"B271","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2861034"},{"key":"B272","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20238"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0000000000001309"},{"key":"B274","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmedr.2021.101492"},{"key":"B275","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0850"},{"key":"B276","doi-asserted-by":"publisher","DOI":"10.1038\/srep27854"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.11.040"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2018.06.108"},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.143836"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.105941"},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.115607"},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-013-1059-8"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfx238"},{"key":"B284","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1307421"},{"key":"B285","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa096"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.1177\/1091581819851502"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2017.08.030"},{"key":"B288","doi-asserted-by":"publisher","DOI":"10.1080\/10934529.2017.1294964"},{"key":"B289","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm128"},{"key":"B290","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901827"},{"key":"B291","unstructured":"Stockholm Convention. Report of the Persistent Organic Pollutants Review Committee on the work of its fourteenth meeting\u2014UNEP\/POPS\/POPRC.14\/6. Geneva: United Nations, 2018."},{"key":"B292","volume-title":"Drinking Water Health Advisory for Perfluorooctanoic Acid (PFOA)","author":"Environmental Protection Agency.","year":"2016"},{"key":"B293","volume-title":"Commission Staff Working Document: Poly- and perfluoroalkyl substances (PFAS)","author":"European Commission","year":"2020"},{"key":"B294","doi-asserted-by":"publisher","DOI":"10.1289\/EHP6785"},{"key":"B295","unstructured":"Department of Health and Human Services. Fourth National Report on Human Exposure to Environmental Chemicals. Washington, DC: Dept. of Health and Human Services, 2019."},{"key":"B296","unstructured":"Health Canada. Second Report on Human Biomonitoring of Environmental Chemicals in Canada: Results of the Canadian Health Measures Survey Cycle 2, 2009\u20132011. Ottawa: Health Canada, 2013."},{"key":"B297","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106123"},{"key":"B298","unstructured":"Centers for Disease Control and Prevention. Early Release: Per- and Polyfluorinated Substances (PFAS) Tables, NHANES 2011-2018. Atlanta, GA: CDC, 2021."},{"key":"B299","doi-asserted-by":"publisher","DOI":"10.1289\/EHP1612"},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2012.03.049"},{"key":"B301","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209255"},{"key":"B302","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2017-104651"},{"key":"B303","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10009"},{"key":"B304","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2010.03.007"},{"key":"B305","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2017.06.007"},{"key":"B306","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1509934"},{"key":"B307","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17218020"},{"key":"B308","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab194"},{"key":"B309","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1430"},{"key":"B310","doi-asserted-by":"publisher","DOI":"10.1038\/nature01478"},{"key":"B311","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1233"},{"key":"B312","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2010.01299.x"},{"key":"B313","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws171"},{"key":"B314","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e3181b5f395"},{"key":"B315","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2007.06.011"},{"key":"B316","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2019.108743"},{"key":"B317","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2016.03.012"},{"key":"B318","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.12.186"},{"key":"B319","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-013-3126-3"},{"key":"B320","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.01.025"},{"key":"B321","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2015.11.016"},{"key":"B322","doi-asserted-by":"publisher","DOI":"10.1289\/EHP2619"},{"key":"B323","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckx066"},{"key":"B324","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1816"},{"key":"B325","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2017.09.019"},{"key":"B326","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.10.074"},{"key":"B327","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2013.11.003"},{"key":"B328","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2009.08.002"},{"key":"B329","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.0901584"},{"key":"B330","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2012.11.006"},{"key":"B331","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2016.05.001"},{"key":"B332","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.12.026"},{"key":"B333","doi-asserted-by":"publisher","DOI":"10.1038\/srep11029"},{"key":"B334","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2017.09.019"},{"key":"B335","doi-asserted-by":"publisher","DOI":"10.1038\/srep04582"},{"key":"B336","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.9b07295"},{"key":"B337","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00384"},{"key":"B338","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.02.028"},{"key":"B339","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.138498"},{"key":"B340","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6452"},{"key":"B341","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246110"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00358.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T23:52:03Z","timestamp":1660607523000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00358.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,1]]},"references-count":338,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5,1]]}},"alternative-id":["10.1152\/ajpendo.00358.2021"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00358.2021","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,1]]},"assertion":[{"value":"2021-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-20","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}