{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:07:01Z","timestamp":1791205621730,"version":"4.1.0"},"reference-count":41,"publisher":"American Physiological Society","issue":"3","funder":[{"DOI":"10.13039\/100009633","name":"HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD112143"],"award-info":[{"award-number":["R21HD112143"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD111199"],"award-info":[{"award-number":["R21HD111199"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R21HD107869"],"award-info":[{"award-number":["R21HD107869"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017618","name":"HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases","doi-asserted-by":"publisher","award":["DK113007"],"award-info":[{"award-number":["DK113007"]}],"id":[{"id":"10.13039\/100017618","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK095132"],"award-info":[{"award-number":["DK095132"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"published-print":{"date-parts":[[2024,3,1]]},"abstract":"<jats:p>Our study reveals a progressive decline in maternal blood glucagon-like peptide 1 (GLP-1) concentration. GLP-1 receptor agonist injection in late pregnancy significantly reduced fetal body weight, even after restoration of maternal blood glucose concentration. GLP-1 receptor activation significantly reduced the placental labyrinth area, expression of some nutrient transporters, and capillary development. Our study indicates that reducing maternal blood GLP-1 levels is a physiological adaptation process that benefits placental development and fetal growth.<\/jats:p>","DOI":"10.1152\/ajpendo.00361.2023","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T09:53:19Z","timestamp":1704880399000},"page":"E268-E276","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":36,"title":["Maternal GLP-1 receptor activation inhibits fetal growth"],"prefix":"10.1152","volume":"326","author":[{"given":"Liping","family":"Qiao","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of California San Diego, La Jolla, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cindy","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California San Diego, La Jolla, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyi","family":"Zang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California San Diego, La Jolla, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna","family":"Dzyuba","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California San Diego, La Jolla, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3586-3602","authenticated-orcid":false,"given":"Jianhua","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of California San Diego, La Jolla, California, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnaa032"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2019.09.010"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/304368a0"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.04.008"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)67324-7"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490160110"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)68261-4"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0167-0115(95)00167-0"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.44.26488"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-020-05196-3"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.4161\/isl.2.3.11396"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-11-0094"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2716-9"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.06.003"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2337\/db21-0923"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1530\/REP-18-0414"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0047"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12082"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0096863"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1042\/CS20220890"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00486.2019"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2018.09.004"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxab029"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0284972"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(05)80085-6"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4061-x"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1093\/biolre\/ioy184"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2009.090206"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.106.054684"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1530\/REP-09-0548"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3390\/nu7053497"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00192.2018"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-00564"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.156424"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405789"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2022.5450"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16105"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.739938"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa246"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.557835"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1161\/atv.0000615456.97862.30"}],"container-title":["American Journal of Physiology-Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpendo.00361.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T10:46:42Z","timestamp":1707994002000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpendo.00361.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3,1]]}},"alternative-id":["10.1152\/ajpendo.00361.2023"],"URL":"https:\/\/doi.org\/10.1152\/ajpendo.00361.2023","relation":{},"ISSN":["0193-1849","1522-1555"],"issn-type":[{"value":"0193-1849","type":"print"},{"value":"1522-1555","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,1]]},"assertion":[{"value":"2023-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}