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These observations led us to further investigate the potential role of CPT1A in adipocytes and macrophages. We expressed CPT1AM, a permanently active mutant form of CPT1A, in 3T3-L1 CAR\u03941 adipocytes and RAW 264.7 macrophages through adenoviral infection. Enhanced FAO in palmitate-incubated adipocytes and macrophages reduced triglyceride content and inflammation, improved insulin sensitivity in adipocytes, and reduced endoplasmic reticulum stress and ROS damage in macrophages. We conclude that increasing FAO in adipocytes and macrophages improves palmitate-induced derangements. This indicates that enhancing FAO in metabolically relevant cells such as adipocytes and macrophages may be a promising strategy for the treatment of chronic inflammatory pathologies such as obesity and type 2 diabetes.<\/jats:p>","DOI":"10.1152\/ajpendo.00362.2014","type":"journal-article","created":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T09:09:49Z","timestamp":1424941789000},"page":"E756-E769","source":"Crossref","is-referenced-by-count":193,"title":["Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation"],"prefix":"10.1152","volume":"308","author":[{"given":"Maria Ida","family":"Malandrino","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Institut de Biomedicina de la Universitat de Barcelona, Universitat de Barcelona, Barcelona, Spain;"},{"name":"Institut de Biomedicina de la Universitat de Barcelona Fisiopatolog\u00eda de la Obesidad y la Nutrici\u00f3n, 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