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All three receptor subtypes contribute in mPVAT and aPVAT, whereas \u03b11a predominates in white adipose tissue. Internal Ca\n                    <jats:sup>2+<\/jats:sup>\n                    stores are the primary Ca\n                    <jats:sup>2+<\/jats:sup>\n                    source for NE-induced signaling across depots. Ca\n                    <jats:sup>2+<\/jats:sup>\n                    imaging with selective agonists supports \u03b11a\u2019s role, and NO imaging highlights depot diversity. Immunofluorescence data confirm receptor expression on adipocytes and vasculature, indicating complex signaling pathways in adipose tissues studied here across depots.\n                  <\/jats:p>","DOI":"10.1152\/ajpendo.00364.2025","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T16:41:01Z","timestamp":1774716061000},"page":"E641-E658","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanisms of norepinephrine-induced Ca\n                    <sup>2+<\/sup>\n                    responses in perivascular adipose tissue"],"prefix":"10.1152","volume":"330","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2348-1363","authenticated-orcid":false,"given":"Julia R.","family":"Jamka","sequence":"first","affiliation":[{"name":"Michigan State University","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma 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